Antimicrobial diterpenes from the stem bark of Mitrephora celebica |
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| Authors: | Zgoda-Pols J R Freyer A J Killmer L B Porter J R |
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| Institution: | Graduate Program in Pharmacognosy, Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, 600 South 43rd Street, PA Philadelphia 19104-4495, USA. |
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| Abstract: | Four diterpenes were isolated from the stem bark of Mitrephora celebica through bioassay-guided fractionation. Ent-trachyloban-19-oic acid (1) and ent-kaur-16-en-19-oic acid (2) were identified as the compounds responsible for the antimicrobial activity of the plant against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis. 8(14),15-pimaradien-18-oic acid (3) and 7,15-pimaradien-18-oic acid (4) were isolated from the same fraction and were inactive against the microorganisms. |
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