Antiproliferative Activity of Korean Wild Vegetables on Different Human Tumor Cell Lines |
| |
| Authors: | Buk-Gu Heo Sang-Uk Chon Yun-Jum Park Jong-Hyang Bae Su-Min Park Yong-Seo Park Hong-Gi Jang Shela Gorinstein |
| |
| Institution: | (1) Naju Foundation of Natural Dyeing Culture, Naju, 520-931, South Korea;(2) EFARINET Co. Ltd., BI Center, Chosun University, Gwangju, 501-759, South Korea;(3) Division of Horticulture and Pet Animal-Plant Science, Wonkwang University, Iksan, 570-749, South Korea;(4) Department of Horticultural Science, Mokpo National University, Muan, 534-729, South Korea;(5) Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University- Hadassah Medical School, Jerusalem, Israel; |
| |
| Abstract: | This study was conducted to determine the antiproliferative activity of 24 Korean wild vegetables. The methanol extracts of
these wild vegetables were used against lung, breast, colon and gastric cancer cells, and the results were assessed by MTT
assay. It was found that at the extract concentration of 400 mgL−1 14 plants exercised antiproliferative activity over 80% against the lung cancer cells, one plant among six—against breast
cancer cells, and two plants among six—against colon cancer cells, respectively. Eighteen wild vegetables had the hyperplasia
inhibition activity against gastric cancer cells over 23.6% at all extract concentrations, however, only six plants had the
antiproliferative activity over 80% in 600 mgL−1. It was found that the extracts from Youngia sonchifolia, Synurus deltoides, Syneilesis palmata, and Cephalonoplos segetum, in concentration of 400 mgL−1 inhibited the hyperplasia of lung cancer cells over 95% and Angelica gigas—both lung and colon cancer cells over 95%. In conclusion, the studied wild vegetables’ methanol extracts possess dose dependent
antiproliferative properties, based on their bioactive compounds, mainly polyphenols, but some of them as Hypericum ascyron against lung cancer are not effective and even course harm. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
