Choriocarcinoma and teratoma in the ovary of a cynomolgus monkey |
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| Authors: | Toyosawa K Okimoto K Koujitani T Kikawa E |
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| Institution: | Department of Toxicology, Dainippon Pharmaceutical Co., Suita, Osaka, Japan. kaoru-toyozawa@dainippon-pharm.co.jp |
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| Abstract: | An ovarian choriocarcinoma was found in a 13-year-old cynomolgus monkey (Macaca fascicularis). The tumor was accompanied by a mature teratoma in the contralateral ovary. Histologically, the choriocarcinoma was characterized by nests of cells where cytotrophoblasts occupied the periphery with syncytiotrophoblasts at the center. Immunohistochemical staining for anti-human chorionic gonadotropin was positive in the syncytiotrophoblasts. The teratoma consisted of well-differentiated epidermal cells, sebaceous glands, hair follicles, cartilage, bone, and teeth. Choriocarcinoma metastases were in multiple organs. The concomitant development of choriocarcinoma and teratoma in the ovary is a consistent finding with the human counterparts of these lesions. |
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