| 毛囊发育与毛发生产研究进展 |
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| 引用本文： | 王宁,荣恩光,闫晓红.毛囊发育与毛发生产研究进展[J].东北农业大学学报,2012(9):6-12,145. |
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| 作者姓名： | 王宁 荣恩光 闫晓红 |
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| 作者单位： | 东北农业大学动物科学技术学院,哈尔滨 150030 |
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| 基金项目： | 转基因生物新品种培育重大专项(2009ZX08009-160B);转基因生物新品种培育重大专项(2011ZX08009-002) |
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| 摘 要： | 毛囊是皮肤的衍生物,其结构复杂,由多层独特的细胞构成.毛囊是哺乳动物惟一终生呈周期性生长的器官.毛发是毛囊生长发育的产物,由死亡的终末分化角质细胞组成.动物毛发是重要的畜产品,是纺织工业的重要原料.近年来,毛囊发育和毛发生产的分子遗传学研究进展迅速,许多调控毛囊形态发生和毛发周期的信号通路以及基因相继被发现和鉴定.这些调控通路及基因的发现和鉴定提高对毛囊发育和毛发生产的了解和认识,为采用分子辅助育种和转基因育种技术培育优质细毛羊奠定了理论基础.文章综述了毛囊形态发生、毛发周期以及毛干特性的调控等最新研究进展,并讨论了未来羊毛囊发育研究方向.
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| 关 键 词： | 毛囊 毛发周期 调控 miRNA 生物钟基因 |
Research progress of hair follicle development and hair production |
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| WANG Ning,RONG Enguang,YAN Xiaohong.Research progress of hair follicle development and hair production[J].Journal of Northeast Agricultural University,2012(9):6-12,145. |
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| Authors: | WANG Ning RONG Enguang YAN Xiaohong |
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| Institution: | (School of Animal Sciences and Technology,Northeast Agricultural University,Harbin 150030,China) |
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| Abstract: | Hair follicle is a skin appendage with a complex structure composed of several distinct cell layers.The hair follicle is a unique mammalian organ that undergoes continuous cycling throughout adult life.Hair follicles produce hair shafts or fibers,which is composed of terminally differentially dead keratinoacytes.Sheep hair(wool) have great economic value,and sheep are the most common resource for wool textile industry.Recently,much progress has been made in understanding hair follicle development and hair production.Many pathways and genes have been identified that are involved in hair follicle development and hair production.These advances have led to a better understanding of hair follicle development and hair production,and lay a solid foundation for inproving the productivity and quality of sheep wool via marker assisted selection and transgenic technologies.This paper summarizes the advances in hair follilce morphogenesis,hair follicle cycle and hair production,and discusses several important directions for future research in the study of sheep hair follicle. |
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| Keywords: | hair follicle hair cycle regualtion miRNA clock gene |
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