| 截短侧耳素的萃取及结晶 |
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| 引用本文： | 张宗鹏,赵才兵,张翠芬,李玉清,郭慧君,刘秋红.截短侧耳素的萃取及结晶[J].中国动物保健,2013(7):27-28,34. |
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| 作者姓名： | 张宗鹏 赵才兵 张翠芬 李玉清 郭慧君 刘秋红 |
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| 作者单位： | 山东胜利生物工程有限公司山东济宁272073 |
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| 摘 要： | 研究截短侧耳素的萃取和结晶。截短侧耳素闪蒸粉分别用甲醇、乙醇和K酮在20℃、40℃和60℃条件下萃取，萃取时间60min，比较萃取率；60℃的K酮饱和溶液，分别降温至50℃、45RE和40℃，加入晶种保温3h，然后以5-8℃／h的速度降温至0℃，然后保温2h，离心获得晶体，50℃干燥1h，获得截短侧耳素粉，分析干燥失重、含量、杂质和收率。K酮在60℃时的萃取率最高，均值为92％；40℃加入晶种保温3h获得产品收率最高95．01％。K酮为更加理想的截短侧耳素萃取剂，萃取温度60℃，晶体成长的第一过程选择40℃。
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| 关 键 词： | 截短侧耳素 萃取 结晶 |
Extraction and Crystallization of Pleuromutilin |
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| Zhang Zongpeng
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Zhao Caibing
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Zhang Cuifen
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Li Yuqing
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Guo Huijun
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Liu Qiuhong.Extraction and Crystallization of Pleuromutilin[J].China Animal Health,2013(7):27-28,34. |
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| Authors: | Zhang Zongpeng Zhao Caibing Zhang Cuifen Li Yuqing Guo Huijun Liu Qiuhong |
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| Institution: | (Shandong Shengli Co,LTD, Jining, Shandong, 272073) |
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| Abstract: | Research extraction and crystallization of pleuromutilin. Pleuromutilin flash powder with methanol, ethanol and K ketone was extracted at 20 ℃, 40 ℃ and 60 ℃, extraction time 60 min, compared extraction rate. K ketone saturated solution at 60 ℃ was cooled to 50 ℃, 45 ℃ and 40℃, respectively, with addition of crystal warmed for 3h, and then cooled to 0 ℃ at the speed of 5-8℃ per 1 hour, then warmed for 2h, centrifugated for crystal, dryed for lh at 50 ℃, obtained pleuromutilin powder, loss on drying, content analysis, impurity and yield. K ketone extraction rate is the highest at 60 ℃, average is 92%. At 40℃ by adding crystal seeds obtained the highest yield products 95.01% for 3h. K ketone as truncated ear is more ideal element extractant, extraction tem- perature 60℃, crystal growth process at 40℃ first choice. |
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| Keywords: | pleuromutilin extraction crystallization |
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