Synthesis,fungicidal activity and structure-activity relationships of a series of 1-(3-pyridyl)-1-substituted-but-3-yn-1-ols |
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| Authors: | Anna Arnoldi Eliseo Betto Lucia Ceresa Gandolfina Farina Attilio Formigoni Remo Galli Leonardo Scaglioni |
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| Abstract: | A series of 1-(3-pyridyl)-1-substituted-but-3-yn-1-ols and some related compounds were synthesised and tested for antifungal activity against eight phytopathogenic fungi of different taxonomic classes. High activity was shown in particular against Sphaerotheca fuliginea on Cucumis sativus. The compounds containing aromatic substituents gave the best results, not only in protectant but also in systemic and eradicant tests. The quantitative structure-activity relationship suggests that steric effects play an important role in determining fungicidal activity. |
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