It is important to analyze regional advantages of corn production in order to achieve reasonable regional production arrangement and promote corn production in Hubei Province. Regional comparative advantages of corn production in Hubei Province in the periods of "Tenth Five Year Plan" and "Eleventh Five Year Plan" were analyzed, using the method of comparative advantage and agricultural production statistic data of 17 regions in Hubei province during the year of 2000 to 2009. The results showed that, corn production in Hubei Province had significant regional difference; five regions had scale comparative advantage, ten regions had efficiency comparative advantage, and five regions had aggregated comparative advantage. The comparative advantageous areas of corn production mainly distribute in the western mountainous and hilly area and northern low hilly area of Hubei Province, where the aggregated comparative advantage index (AAI) was 2.43 in the period of "Tenth Five Year Plan", and raised to 2.77 in the period of "Eleventh Five Year Plan". Compared with that in the period of "Tenth Five Year Plan", AAI in "Eleventh Five Year Plan" period was increased by 0.08 for corn production, 0.03 for rice production, while was declined by 0.05 for cotton production. Through cost-benefit analysis, it showed that net income per hectare of corn production was 507.0 Yuan and 2143.5 Yuan lower than that of rice and cotton respectively, but the labor cost of corn production was 535.5 Yuan and 4096.5 Yuan lower than that of rice and cotton respectively. On the basis of the above analysis, some proposals were put forward to develop maize production in Hubei Province.