Pharmacokinetic interaction of isopropylaminophenazone and phenylbutazone in the horse |
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| Authors: | EDUARD JENNY VOLKER W STEINIJANS PHILIPPE SEIFERT † |
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| Institution: | Institute of Pharmacology and Biochemistry, Faculty of Veterinary Medicine, University of Zürich, Switzerland;*Biometry Dept, Byk Gulden Pharmaceuticals, Konstanz, Germany |
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| Abstract: | The pharmacokinetics of the two active anti-inflammatory compounds, isopropylaminophenazone and phenylbutazone, were investigated in the horse. Therapeutic intravenous doses of 12 mg/kg body weight and 6 mg/kg body weight, respectively, were given separately and as a combination to five horses. Blood concentrations were described by two-compartment kinetics. Significantly lower total clearances, unchanged volumes of distribution, and hence significantly higher elimination half-lives were found for both substances when administered as a combination. It is possible that the hydroxylated metabolites of the substances are responsible for the presumed metabolic interference. |
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