Theacrine,a purine alkaloid with anti-inflammatory and analgesic activities |
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| Authors: | Yuanyuan Wang Xiaorong Yang Xinqiang Zheng Jing Li Chuangxing Ye Xiaohong Song |
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| Institution: | 1. School of Life Sciences, Sun Yat-sen University, Guangzhou, China;2. Tea Research Institute, Zhejiang University, Hangzhou, China;3. Department of Biology, School of chemistry and biology sciences, I Li Normal University, Yining 835000, China |
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| Abstract: | The anti-inflammatory and analgesic effects of theacrine (1, 3, 7, 9-tetramethyluric acid), a purine alkaloid which is abundantly present in Camellia kucha, were investigated. Xylene-induced ear edema, acetic acid-induced vascular permeability and λ-carrageenan-induced paw edema were used to investigate anti-inflammatory activity, and acetic acid-induced writhing and hot-plate tests were used to determine analgesic effect. Oral administration of theacrine (8–32 mg/kg) induced dose-related anti-inflammatory and analgesic effects. On the other hand, oral caffeine administration (8–32 mg/kg) did not show an inhibitory effect on the inhibition of inflammatory response or cause analgesia. Additionally, the result of the acute toxicity test showed that the LD50 of theacrine was 810.6 mg/kg (769.5–858.0 mg/kg). The data obtained suggest theacrine possessed analgesic and anti-inflammatory activities. |
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| Keywords: | Purine alkaloid Theacrine Camellia kucha Anti-inflammation Analgesia |
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