Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity |
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| Authors: | Jasmina Nestorović Danijela Mišić Branislav Šiler Marina Soković Jasmina Glamočlija Ana Ćirić Vuk Maksimović Dragoljub Grubišić |
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| Institution: | 1. Institute for Biological Research “Siniša Stankovi?”, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia;2. Institute for Multidisciplinary Research, University of Belgrade, Kneza Višeslava 1a, 11000 Belgrade, Serbia;3. Faculty of Biology, Institute of Botany, University of Belgrade, Takovska 43, 11000 Belgrade, Serbia |
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| Abstract: | Rapid micropropagation of Nepeta rtanjensis, N. sibirica and N. nervosa was performed. Qualitative and quantitative nepetalactone content in methanol extracts of in vitro grown plants was analysed by reverse-phase HPLC coupled with UV and MS detection. Only trans,cis-nepetalactone was detected in shoots of N. rtanjensis, while cis,trans-nepetalactone stereoisomer was present in N. sibirica. No nepetalactone was observed in shoots of N. nervosa. The antimicrobial activity of methanol extracts, against eight bacterial and eight fungal species, was evaluated. All the tested extracts showed significant antibacterial and strong antifungal activity. However, N. rtanjensis extract exhibited the best antimicrobial potential. |
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| Keywords: | Nepeta rtanjensis Nepeta sibirica Nepeta nervosa Nepetalactone Antimicrobial activity |
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