Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice |
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| Authors: | MR Sulaiman EK Perimal MN Akhtar AS Mohamad MH Khalid NA Tasrip F Mokhtar ZA Zakaria NH Lajis DA Israf |
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| Institution: | 1. Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;2. Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Malaysia |
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| Abstract: | The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. |
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| Keywords: | Zerumbone Anti-inflammatory activity Carrageenan-induced paw edema test Cotton pellet-induced granuloma test |
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