| 苦马豆素抗肿瘤作用研究进展 |
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| 引用本文： | 路浩,王建军,孙莉莎,赵宝玉,王占新,马尧,陈基萍,刘忠艳.苦马豆素抗肿瘤作用研究进展[J].动物医学进展,2009,30(9):87-90. |
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| 作者姓名： | 路浩 王建军 孙莉莎 赵宝玉 王占新 马尧 陈基萍 刘忠艳 |
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| 作者单位： | 1. 西北农林科技大学动物医学院,陕西杨陵,712100
2. 西安市公安局,陕西西安,710002 |
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| 基金项目： | 农业部援藏项目，西北农林科技大学人才基金资助项目 |
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| 摘 要： | 苦马豆素(SW)是一种吲哚里西啶生物碱,最早是从灰苦马豆中分离得到,是疯草类植物的主要毒性成分.它能抑制肿瘤细胞表面糖蛋白的表达,从而抑制肿瘤细胞的生长与转移.此外,SW能促进脾细胞增殖,增强巨噬细胞对肿瘤细胞的杀伤活性,还能促进机体淋巴细胞活性升高,刺激机体骨髓细胞增殖,增强机体杀灭肿瘤细胞的能力.由于SW具有很好的抗肿瘤活性和免疫增强作用,已引起国内外学者的广泛关注,并作为抗肿瘤药物筛选的后备药物.目前,国外SW抗肿瘤药物的研发已进入Ⅲ期临床试验阶段,而国内才刚起步.论文主要介绍了SW抗肿瘤作用及其临床治疗效果,并对SW下一步研究重点及应用前景进行了展望.
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| 关 键 词： | 苦马豆素 抗肿瘤 免疫细胞 |
Progress on Antineoplastic Activity of Swainsonine |
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| LU Hao,WANG Jian-jun,SUN Li-sha,ZHAO Bao-yu,WANG Zhan-xin,MA Yao,CHEN Ji-ping,LIU Zhong-yan.Progress on Antineoplastic Activity of Swainsonine[J].Progress In Veterinary Medicine,2009,30(9):87-90. |
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| Authors: | LU Hao WANG Jian-jun SUN Li-sha ZHAO Bao-yu WANG Zhan-xin MA Yao CHEN Ji-ping LIU Zhong-yan |
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| Institution: | LU Hao1,WANG Jian-jun2,SUN Li-sha1,ZHAO Bao-yu1,WANG Zhan-xin1,MA Yao1,CHEN Ji-ping1,LIU Zhong-yan1(1.College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi,712100,China,2.Xi'an Public Security Bureau,Xi'an,710002,China) |
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| Abstract: | The indolizidine alkaloid swainsonine was initially isolated from Swainsona canescens,which is primary toxic ingredient of locoweed plants.Swainsonine can inhibit the expression of tumor cell glycoprotein and restrain the tumor cells from growth and transfer.In addition,it can promote proliferation of splenocytes,enhance killing activity of macrophages to tumor cells,increase activity of lymphocytes,stimulate generation of bone marrow cells,and accentuate the ability of killing tumor cells.Because of its sa... |
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| Keywords: | swainsonine anticancer immunocyte |
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