| 冬虫夏草水提取物与速溶芦笋粉抗焦虑活性研究 |
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| 引用本文： | 汤建亚,胡玉婷,何晨梦,孙进,马淑凤,黄云祥.冬虫夏草水提取物与速溶芦笋粉抗焦虑活性研究[J].安徽农业科学,2014(14):4224-4225,4228. |
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| 作者姓名： | 汤建亚 胡玉婷 何晨梦 孙进 马淑凤 黄云祥 |
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| 作者单位： | 江南大学食品科学与技术国家重点实验室;江南大学食品学院;河北省芦笋工程技术研究中心; |
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| 基金项目： | 中央高校基本科研业务费专项资金资助项目(JUSRP2111 5);秦皇岛市科学技术研究与发展计划项目(No.20121107001);江苏高校优势学科建设工程资助项目;公益性行业(农业)科研专项经费项目“蔬菜副产物综合利用技术研究与示范(201303079);河北省重大科技成果转化专项项目(13042805Z) |
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| 摘 要： | 目的]研究冬虫夏草水提取物与速溶芦笋粉的抗焦虑作用.方法]取健康雄性SD大鼠70只,按体重随机分为7组,模型对照组,冬虫夏草低剂量组（8.4 mg/kg WECS-1）,冬虫夏草高剂量组（16.8 mg/kg WECS-h）,冬虫夏草水提取物低剂量＋速溶芦笋粉（8.4mg/kg WECS-1 ＋400 mg/kg IAP）,冬虫夏草高剂量＋速溶芦笋粉（16.8 mg/kg WECS-h ＋400 mg/kg IAP）,速溶芦笋粉（400 mg/kgIAP）,空白对照组.采用慢性情绪应激模型,从行为学观察和内分泌水平角度研究速溶芦笋粉的抗焦虑作用.结果]行为学观察表明,与模型对照组比较,在此焦虑模型上WECS-h ＋IAP剂量组的攻击行为显著降低（P＜0.05）,WECS-1＋ IAP剂量组的探究行为和修饰行为显著降低（P＜0.05）,其他各个处理组与模型对照组比较统计结果均没有显著的差异（P＞0.05）.内分泌水平检测结果表明,与模型对照组比较,在此焦虑模型上冬虫夏草水提取物与速溶芦笋粉（WECS-h ＋IAP）剂量组能显著降低血清种皮质醇（CORT）、肾上腺素（E）和去甲肾上腺素（NA）浓度（P＜0.05）,并能显著升高血清中5-羟色氨酸（5-HT）和多巴胺（DA）水平（P＜0.05）.结论]冬虫夏草水提取物与速溶芦笋粉联用具有增强抗焦虑作用.
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| 关 键 词： | 冬虫夏草水提取物 速溶芦笋粉 抗焦虑 小鼠 |
Study on Anxiolytic Activity of Water Extract from Cordyceps sinensis and the Instant Asparagus Powder in Rats |
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| Institution: | TANG Jian-ya,SUN Jin et-al (State Key Laboratory of Food-Science and Technology,Jiangnan University, Wuxi, Jiangsu 214122; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122) |
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| Abstract: | Objective] To study anxiolytic activity of water extract from Cordyceps sinensis and the instant asparagus powder.Method] 70healthy Sprague-Dawley male rats were randomly divided into 7 groups according to their weight for daily intragastric administration of drugs：model control group,water extract from Cordyceps sinensis low-dose （WECS-1 8.4mg/kg）,high-dose （WECS-h 16.8 mg/kg）,the water extract from Cordyceps sinensis low-dose with the instant asparagus powder （WECS-1 8.4 mg/kg ＋ IAP 400 mg/kg）,the water extract from Cordyceps sinensis high-dose with the instant asparagus powder （WECS-h 16.8mg/kg ＋IAP 400mg/kg）,the instant asparagus powder （IAP 400mg/kg） and normal control group.In this test,adopting the model of chronic emotional stress,the effect of anti-anxiety of the instant asparagus powder on the behavior and endocrine level was observed.Result] The results of behavior showed the water extract from Cordyceps sinensis high-dose with the instant asparagus powder group （WECS-h ＋ IAP） attacks were significantly reduced,and WECS-1 ＋IAP group the exploration and preening behavior also significantly reduced,but the other groups has no significant differences while compared with the model control group （P ＞ 0.05）.The results of endocrine level showed that on the anxiety model,the WECS-h ＋IAP group obviously decreased the concentrations of cortisol,epinephrine and noradrenaline in rats＇ serum （P ＜0.05）,the concentrations of 5-HT and dopamine in rats＇ serum was obviously increased at the same time （P ＜0.05）.Conclusion] The combined use of the water extract from Cordyceps sinensis and the instant asparagus powder has obvious anti-anxiety activity. |
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| Keywords: | Water extract from Cordyceps sinensis Instant asparagus powder Anti-anxiety Rats |
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