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Regression of venous thrombus after trans-sphenoidal hypophysectomy for pituitary-dependent hyperadrenocorticism in a dog |
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| Authors: | S Tanaka S Suzuki T Teshima R Yamashita Y Hamamoto Y Hara |
| Institution: | 1. Laboratory of Veterinary Surgery, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, 180-8602 Japan;2. Laboratory of Veterinary Surgery, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, 180-8602 Japan
Contribution: Conceptualization (lead), ?Investigation (equal), Methodology (equal), Project administration (lead), Supervision (equal), Validation (equal), Visualization (equal), Writing - review & editing (equal);3. Laboratory of Veterinary Internal Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, 180-8602 Japan Contribution: Conceptualization (equal), Formal analysis (equal), ?Investigation (equal), Methodology (equal), Project administration (equal), Writing - original draft (equal), Writing - review & editing (lead);4. Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Tokyo, 180-8602 Japan Contribution: Data curation (equal), ?Investigation (supporting), Project administration (supporting), Validation (equal), Visualization (supporting), Writing - review & editing (supporting);5. Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Tokyo, 180-8602 Japan Contribution: Data curation (supporting), ?Investigation (supporting), Validation (supporting), Visualization (lead), Writing - review & editing (supporting);6. Laboratory of Veterinary Surgery, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo, 180-8602 Japan Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), ?Investigation (lead), Methodology (lead), Project administration (lead), Validation (lead), Writing - original draft (supporting), Writing - review & editing (lead) |
| Abstract: | An 8.0-kg 8-year-old male dachshund was presented for surgical treatment of suspected pituitary-dependent hyperadrenocorticism with portal vein thrombosis. Advanced diagnostic imaging revealed a thrombus in the splenic and portal veins. For the portal vein thrombus, CT angiography showed an enhanced timing delay in the lateral right and caudate liver lobes. Blood tests showed a marked increase in the liver panel, including total bile acid. Brain MRI revealed a pituitary mass, suggesting pituitary-dependent hyperadrenocorticism. The mass was completely resected. The preoperative antithrombotic therapy of rivaroxaban (0.66 mg/kg, PO, once per day) and clopidogrel sulphate (1.66 mg/kg, PO, once per day) was continued postoperatively. Six months after resection of the pituitary mass, the thrombus had disappeared. Further studies are required to prove a causal association between the disappearance of the thrombus and the treatments provided. |
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