| 重庆市223例新型冠状病毒肺炎患者的临床特征分析 |
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| 引用本文： | 袁婧,孙艳雨,左玉洁,陈婷颖,曹齐,袁国丹,杨梅,张维,彭安周,陈耀凯.重庆市223例新型冠状病毒肺炎患者的临床特征分析[J].西南农业大学学报,2020,42(3):17-24. |
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| 作者姓名： | 袁婧 孙艳雨 左玉洁 陈婷颖 曹齐 袁国丹 杨梅 张维 彭安周 陈耀凯 |
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| 作者单位： | 1. 重庆市公共卫生医疗救治中心/西南大学附属公卫医院 感染科, 重庆 400036;2. 重庆医药高等专科学校 附属第一医院重症医学科, 重庆 400038;3. 西南大学 医学研究院, 重庆 400715 |
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| 基金项目： | 重庆市新型冠状病毒感染肺炎疫情应急科技公关专项（cstc2020jscx-fyzx0074）. |
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| 摘 要： | 目的:回顾性总结分析该院收治的新型冠状病毒肺炎患者临床特征、治疗方案和转归.方法:收集2020年1月24日-2020年2月23日重庆市公共卫生医疗救治中心收治的全部新型冠状病毒感染患者的临床资料,比较轻型和普通型病例(普通组)与(危)重型病例(重症组)在流行病学史、临床表现、实验室检测结果、影像学特征、治疗方式和疗效等方面是否存在差异.结果:共有223例新型冠状病毒肺炎(NCP)住院患者纳入该研究,平均年龄(46.5±16.1)岁,男性占47.5%(106/223),发病时最常见症状为发热(119, 53.4%)和咳嗽(113, 50.7%), 87.9%(196/223)的患者胸部CT表现为双肺受累.与普通组比较,重症组患者平均年龄较大,合并基础疾病者较多(p0.05);实验室检查发现重症组患者淋巴细胞计数、白蛋白、氧合指数偏低,丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、降钙素原(PCT)水平较普通组升高(p0.05). 223例NCP感染患者均接受抗病毒治疗,其中68.6%(153/223)感染者进行了氧疗.截至2020年2月23日,共有112例(50.2%)患者出院,死亡0例.出院患者中,重症组出院患者平均住院天数(16.4±2.7)天明显长于普通组(13.8±3.9)天(p=0.034),但两组患者入院后核酸转阴时间差异不具有统计学意义(p=0.076).结论:NCP患者通常以发热、咳嗽为首发症状,约14.3%的NCP患者易发展为(危)重型NCP;与普通组患者比较,重症组患者年龄更大、实验室检查结果更差.
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| 关 键 词： | 新型冠状病毒肺炎(NCP) 临床特征 治疗 |
| 收稿时间： | 2020/3/3 0:00:00 |
A Retrospective Analysis of the Clinical Characteristics of 223 NCP Patients in Chongqing |
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| YUAN Jing,SUN Yan-yu,ZUO Yu-jie,CHEN Ting-ying,CAO Qi,YUAN Guo-dan,YANG Mei,ZHANG Wei,PENG An-zhou,CHEN Yao-kai.A Retrospective Analysis of the Clinical Characteristics of 223 NCP Patients in Chongqing[J].Journal of Southwest Agricultural University,2020,42(3):17-24. |
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| Authors: | YUAN Jing SUN Yan-yu ZUO Yu-jie CHEN Ting-ying CAO Qi YUAN Guo-dan YANG Mei ZHANG Wei PENG An-zhou CHEN Yao-kai |
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| Institution: | 1. Chongqing Public Health Medical Center/the Affiliated Public Health Clinic of Southwest University/Infectious Disease Department, Chongqing 400036, China;2. Department of Critical Medicine, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing 400038, China;3. Medical Institute, Southwest University, Chongqing 400715, China |
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| Abstract: | Objective:To retrospectively analyze the clinical characteristics and treatment data of NCP (novel coronavirus pneumonia) patients. Methods:Clinical data of 223 NCP patients admitted by Chongqing Public Health Medical Center was collected. The patients were divided into a critically ill group and a noncritically ill group, and their epidemiological history, clinical manifestation, laboratory and imaging examination, and clinical efficacy were compared. Results:The mean age of the 223 hospitalized patients with NCP was 46.5±16.1 years and 106 (47.5%) of them were men. Their common symptoms included fever (11953.4%]) and dry cough (11359.4%]). Chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in 87.9%(196/223)of the patients. Compared with the noncritically ill patients, the critically ill patients were older and more likely to have underlying comorbidities (p<0.05). Laboratory examination showed that compared with the noncritically ill group, patients of the critically ill group had lymphopenia, hypoproteinemia and hypoxemia, but had higher levels of Alt, AST, CK, LDH and PCT (p<0.05). All the patients received antiviral therapy and many (68.6%) received oxygen therapy. A hundred and twelve patients (50.2%) were discharged by February 23, with no death. The patients of the critically ill group had longer HLOS, averaging 16.4±2.7 days, than the patients of the non-critically ill group (13.8±3.9 days) (p=0.034), but no significant difference existed in the time of the negative of virus index between the two groups (p=0.076). Conclusions:The majority of patients with NCP present fever and dry cough as the first symptoms. One seventh of the patients are likely to develop severe NCP. Compared with noncritically ill patients, critically ill patients are generally older, and have worse laboratory test results. |
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| Keywords: | novel coronavirus pneumonia (NCP) clinical characteristics retrospective analysis |
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