A Preliminary Study of 13C-Phenylalanine and
13C-Dipeptide Breath Tests in Horses |
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Authors: | Naoki SASAKI Nao TSUZUKI Michiaki YAMADA Takuto MINAMI Haruo YAMADA |
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Institution: | 1. Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan |
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Abstract: | This study aimed to establish a standard dose and sample collection time for
13C phenylalanine and 13C-Dipeptide breath test in horses. To
evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
13C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 mg/kg, 2.5
mg/kg, and 5 mg/kg 13C dipeptide dissolved in 2 ml/ kg distilled water. Tmax
was observed during the sample collection time. For 13C phenylalanine, the
standard deviation of Cmax at 5 mg/kg was lower than that of 10 mg/kg. For 13C
dipeptide, the standard deviation of Tmax was the lowest at 5 mg/kg. This study revealed
that an optimal dose for breath tests with 13C phenylalanine and 13C
dipeptide may be 5 mg/kg in horses. |
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Keywords: | 13C- breath test dipeptide horses phenylalanine |
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