Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia |
| |
| Authors: | Tan Hooi Poay Wong Daniel Zin Hua Ling Sui Kiong Chuah Cheng Hock Kadir Habsah Abdul |
| |
| Institution: | a Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysiab Phytochemistry Program, Natural Products Division, Forest Research Institute Malaysia, 52109, Kepong, Selangor, Malaysiac Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia |
| |
| Abstract: | The galloylated cyanogenic glucosides based on prunasin (1-7), gallotannins (8-14), ellagitannins (15-17), ellagic acid derivatives (18, 19) and gallic acid (20) isolated from the leaves of Phyllagathis rotundifolia (Melastomataceae) were investigated for their neuroprotective activity against hydrogen peroxide (H2O2)-induced oxidative damage in NG108-15 hybridoma cell line. Among these compounds, the gallotannins and ellagitannins exhibited remarkable neuroprotective activities against oxidative damage in vitro as compared to galloylated cyanogenic glucosides and ellagic acid derivatives in a dose-dependent manner. They could be explored further as potential natural neuroprotectors in various remedies of neurodegenerative diseases. |
| |
| Keywords: | Phyllagathis rotundifolia Galloylated cyanogenic glucosides Hydrolysable tannins Neuroprotective NG108-15 hybridoma cell line H2O2 |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
