New antioxidant and antiglycation active triterpenoid saponins from the root bark of Aralia taibaiensis |
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| Authors: | Bi Linlin Tian Xiangrong Dou Fang Hong Liangjian Tang Haifeng Wang Siwang |
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| Institution: | a Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, PR Chinab Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR Chinac Research & Development Center of Biorational Pesticide, College of Plant Protection, Northwest A & F University, Yangling 712100, PR China |
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| Abstract: | Four new oleanane type triterpenoid saponins (1-4) and a known saponin (5) were isolated from the root bark of Aralia taibaiensis Z.Z. Wang et H.C. Zheng. The structures of the four new compounds were elucidated as 3-O-{β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 3)]-β-d-glucurono-pyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-β-d-glucopyranosyl ester (1), 3-O-{β-d-gluco-pyranosyl-(1 → 3)-α-l-arabinofuranosyl-(1 → 4)]-β-d-glucuronopyranosyl}-olean-11,13(18)-diene-28-oic acid 28-O-β-D-glucopyranosyl ester (2), 3-O-{β-d-glucopyranosyl-(1 → 2)-α-l-arabinofuranosyl-(1 → 4)]-β-d-glucuronopyranosyl}-oleanolic acid 28-O-β-D-glucopyranosyl ester (3) and 3-O-{β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-oleanolic acid 28-O-β-d-glucopyranosyl ester (4), on the basis of extensive spectral analysis and chemical evidence. Compounds 1-5 exhibited moderate effects on antioxidant and antiglycation activities, which correlated with treatment of diabetes mellitus. |
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| Keywords: | Aralia taibaiensis Triterpenoid saponin Antioxidant Antiglycation Diabetes mellitus |
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