| 线粒体复合体Ⅰ呼吸抑制剂的研究 |
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| 引用本文： | 张帅,曾鑫年,骆悦.线粒体复合体Ⅰ呼吸抑制剂的研究[J].植物保护,2004,30(6):11-14. |
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| 作者姓名： | 张帅 曾鑫年 骆悦 |
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| 作者单位： | 华南农业大学昆虫毒理实验室,广州,510642 |
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| 摘 要： | 线粒体复合体Ⅰ呼吸抑制剂不仅在医药上有着重要的研究价值,在农药方面也有着特殊的意义。这类药剂的作用机制比较特殊,害虫不易产生抗性,是一类非常有前途的杀虫药剂。从植物,微生物等生物体中发现了许多线粒体复合体Ⅰ呼吸抑制剂,如鱼藤酮、粉蝶霉素A、辣椒碱,番荔枝内酯、myxalamid等,它们可以作为农药的先导化合物进行药物合成。根据不同的作用方式,线粒体复合体Ⅰ呼吸抑制剂可分3种类型,分别以粉蝶霉素A、鱼藤酮、辣椒碱为代表。
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| 关 键 词： | 农药学 线粒体复合体Ⅰ 呼吸抑制剂 作用机制 |
A study on the natural respiratory inhibitors of mitochondrial complex Ⅰ |
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| ZHANG Shuai;ZENG Xin-nian;LUO Yue.A study on the natural respiratory inhibitors of mitochondrial complex Ⅰ[J].Plant Protection,2004,30(6):11-14. |
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| Authors: | ZHANG Shuai;ZENG Xin-nian;LUO Yue |
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| Institution: | Laboratory of Insect Toxicology;South China Agricultural University;Guangzhou 510642;China |
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| Abstract: | The respiratory inhibitors of mitochondrial complex I not only have important significance in medical study, but also have valuable function in pesticides. Because of its specific mechanism of action, this type of pesticides has not caused resistance in insects. They can be promising insecticides in the future. The secondary metabolites from microbial and plant sources known to act on complex I exhibit biological activity against agricultural insect pests, such as the classical rotenone, piericidin A, capsaicin, annonaceous acetogenins and myxalamid. They act as lead compounds to synthesize the novel insecticides in the industry. These inhibitors are classified according to three fundamental types of action, represented by piericidin A, rotenone and capsaicin, respectively. |
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| Keywords: | pesticide science mitochondrial complex Ⅰ respiratory inhibitors mechanism of action |
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