| 采用电位法测定氟苯尼考及其制剂的含量 |
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| 引用本文： | 朱力军.采用电位法测定氟苯尼考及其制剂的含量[J].中国兽药杂志,2000,34(4):27-29. |
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| 作者姓名： | 朱力军 |
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| 作者单位： | 中国兽药监察所!北京100081 |
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| 摘 要： | 用电位法测定氟苯尼考的含量。将本品用乙醇溶解，加５０％氢氧化钾溶液２０ｍｌ、加热回流４ｈ，冷却，加水１００ｍｌ稀释，用稀硝酸中和后，用加稀硝酸７．５ｍｌ，照电位滴定法，用银－玻璃电极，以硝酸银滴定液滴定。测得氟苯尼考预混剂回收率为９９．０％，ＲＳＤ为０．４１％，注射液回收率为１００．０％，ＲＳＤ为０．２８％，该法准确度高，重视性好。
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| 关 键 词： | 电位法 氟苯尼考 含量测定 合成抗生素 兽药 |
Determination of Florfenicol Content by Potentiometric Titration |
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| ZHU Li\|jun.Determination of Florfenicol Content by Potentiometric Titration[J].Chinese Journal of Veterinary Drug,2000,34(4):27-29. |
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| Authors: | ZHU Li\|jun |
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| Abstract: | The principle of potentiometric titration to determine florfenicol is to measure the potential variation of indicator electrode caused by the combination of Cl - and Ag . The Cl - is dissociated from florfenicol which is heated and refluxed in alkaline circumstance. Dissolve the sample in alcohol, add 20ml of 50% potassium hydroxide solution, heat and reflux for 4 hours, cool, dilute with 100ml of distilled water, neutralize with diluted nitric acid , add 7.5ml of diluted nitric acid, choice silver glass electrode and titrate with silver nitrate solution (0.1mol/L). The test result shows recovery 99.0% and RSD 0.41%for florfenicol premix; recovery 100.0% and RSD 0.28% for florfenicol injection. This assay approach is high in accuracy and well in reappearance. |
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| Keywords: | potentiometric titration Florfenicol determination |
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