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Effect of Porcine Small Intestinal Submucosa on Acute Full-Thickness Wounds in Dogs |
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| Authors: | SANDRA P SCHALLBERGER Dr Med Vet FVH BRYDEN J STANLEY BVMS MVetSc Diplomate ACVS JOE G HAUPTMAN DVM MS Diplomate ACVS BARBARA A STEFICEK DVM PhD Diplomate ACVP |
| Institution: | Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI;and;Diagnostic Center for Population and Animal Health, College of Veterinary Medicine, Michigan State University, 4125 Beaumont Road, East Lansing, MI |
| Abstract: | Objective— To evaluate the effects of porcine small intestinal submucosa (PSIS) on the healing of full-thickness wounds in dogs, specifically the appearance of granulation tissue, percent epithelialization and contraction, histologic variables of inflammation and repair, and aerobic culture results. Study Design— Prospective, controlled, experimental study. Animals— Purpose-bred, female dogs (n=10). Methods— Wounds were created bilaterally on the trunk; 1 side as a control and 1 treated with PSIS. First appearance of granulation tissue was recorded. Total wound area, open wound area, and epithelialized area were measured at 21 time points—wound contraction and percent epithelialization were calculated. Aerobic cultures were taken at 4 time points and wound biopsies at 8. Histologic features were graded into an Acute Inflammation Score and Repair Score. Results— There was no difference in first appearance of granulation tissue between PSIS-treated and control wounds. Wound contraction was significantly faster in control wounds as was percent epithelialization after day 21. Histologic Acute Inflammation Scores were significantly higher in PSIS-treated wounds compared with control wounds on days 2 and 6. There were no differences in Histologic Repair Scores between PSIS-treated and control wounds or in aerobic culture results. Conclusion— Wounds treated with PSIS contract more slowly, epithelialize less, and have more pronounced acute inflammation after implantation than control wounds. Clinical Relevance— Acute, full-thickness wounds in dogs do not benefit from treatment with PSIS. |
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