| 阿斯匹林在黄牛体内的药代动力学研究 |
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| 引用本文： | 李逐波,张福华.阿斯匹林在黄牛体内的药代动力学研究[J].四川农业大学学报,1995,13(3):377-380. |
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| 作者姓名： | 李逐波 张福华 |
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| 作者单位： | 四川畜牧兽医学院!荣昌,632460,四川农业大学!雅安市,625014 |
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| 摘 要： | 本文报道用高压液相色谱法研究了黄牛一次口服阿斯匹林片剂（100mg/kg）后药代动力学规律。测定条件：Nucleosil-C18,7μm,4×250mm不锈钢柱;流动相：乙腈—0．05％磷酸（30：70,V：V）;紫外检测波长：237nm。主要动力学参数：t1／2Ke,4．295±1．043hr;Tmax,4．375±0．773hr;Cnax29．18±5．121μg／ml;AUC,366．532±86．554μg／ml．hr。
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| 关 键 词： | 动力学［31BC］ 代谢［45EG］ 色谱法［34BC 45AH 65CH］ 阿斯匹林［47UB］ 药物代谢动力学［47UA］ |
STUDY ON PHARMACOKINETICS OF ASPIRIN IN BOS. TAURUS |
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| Li Zhubo, Zhang Fuhua.STUDY ON PHARMACOKINETICS OF ASPIRIN IN BOS. TAURUS[J].Journal of Sichuan Agricultural University,1995,13(3):377-380. |
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| Authors: | Li Zhubo Zhang Fuhua |
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| Abstract: | This paper reports a method for determination of aspirin and its main metabolites--Salicylic acid in plasma of seven healthy bos. Taurus given aspirin as tablet, at a dose of 100 mgkg-1 body weight by HPLC. The detenmination factors are asfollows. Nucleosil-C18 as solid phase and the mobile phase consisted of acetonitrile-0.05% phosphate acid (30: 70, v: v) at a flow rate 1. 0 mlmin-1. The waveleng th of uvdector was 237nm. The experimental data were processed by using "WTS. TM. BAS" pharmacokinetics auto-program. The result indicates that the C-T curve is in accordance with one-compartment open model with first order absorption. The major parameters are:K=0. 170±0. 038 (hr-1) Ka=0. 316±0. 044 (hr-1) T1/2ke = 4. 295±1. 043 (hr) T1/2ka = 2. 1046±0. 6458 (hr) Tmax= 4. 375±0. 773 (hr) Cmax= 29. 181±5. 121 (μ gml-1) AUC= 366. 532±86. 554 (μ gml-1hr-1) |
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| Keywords: | DYNANICS METABOLISM CHROMATOGRAPHY PHARMACOKINETICS ASPIRIN |
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