| 板蓝根滴丸制备工艺优化研究 |
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| 引用本文： | 王占一.板蓝根滴丸制备工艺优化研究[J].安徽农业科学,2010,38(22):11773-11774,11777. |
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| 作者姓名： | 王占一 |
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| 作者单位： | 枣庄学院生命科学系,山东枣庄,277160 |
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| 摘 要： | 目的]研究影响板蓝根滴丸制备的各种因素,确立最佳制备工艺。方法]以外观质量、溶散时限和丸重差异为评价指标,采用正交设计试验对各影响因素进行考察。结果]以聚乙二醇6000＋聚乙二醇4000（9：1）为基质,药物与基质比例为1：3,药液温度为80℃,二甲基硅油为冷凝剂,冷却液温度为5℃,滴速为50d/min,滴距为7cm,制得的滴丸外观质量好、溶散时限短、丸重差异小,与颗粒剂比较吸湿性小。结论]该滴丸质量稳定,重现性好,设备简单,适于工业化生产。
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| 关 键 词： | 板蓝根 滴丸 制备工艺 正交试验 |
Study on the Optimization of the Preparation Technology of Radix isatidis Dropping Pills |
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| WANG Zhan-yi.Study on the Optimization of the Preparation Technology of Radix isatidis Dropping Pills[J].Journal of Anhui Agricultural Sciences,2010,38(22):11773-11774,11777. |
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| Authors: | WANG Zhan-yi |
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| Institution: | WANG Zhan-yi (Department of Life Science,Zaozhuang College,Zaozhuang,Sh,ong,277160) |
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| Abstract: | Objective] The research aimed to study the effects of various influencing factors of Radix isatidis dropping pills and establish the best preparation technology.Method] Using appearance quality,disintegration time limit and weight difference of pills as evaluation indices,various influencing factors were investigated by using orthogonal test.Result] PEG6000:PEG4000 of 9:1 was used as substrate,the ratio of drug to matrix was 1:3,temperature of mixture was 80 ℃,dimethylsilicone oil was used as condensing agent,the temperature of coolant was 5 ℃,dropping speed was 50 drop/min and drop distance was 7 cm.The prepared dropping pills had good appearance quality,short disintegration time limit and small weight difference of pills.The hygroscopicity was smaller than that of granules.Conclusion] The prepared dropping pills had stable quality,good reproducibility and simple device.And they were suitable for the industrialization production. |
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| Keywords: | Radix isatidis Dropping pills Preparation technology Orthogonal test |
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