Organogenesis of lung and kidney in Thoroughbreds and ponies |
| |
| Authors: | Beech D J Sibbons P D Rossdale P D Ousey J C Holdstock N B Chavatte P Ansari T |
| |
| Institution: | Fetal and Infant Toxico-Pathology, University of Liverpool, UK. |
| |
| Abstract: | Equine lung and kidney organogenesis has not previously been examined with the use of unbiased stereological techniques. The present study examined healthy (control) pony and Thoroughbred lungs and kidneys to establish baseline data of organ development from before birth until maturity at age 3-18 years. Whole left lungs and kidneys were collected from 45 equine postmortem examinations (34 Thoroughbred, 11 pony). Stereological techniques were used to estimate whole kidney, cortex and medulla volume, total glomerular number and volume-weighted mean glomerular volume, lung volume, total terminal bronchiolar duct ending number and total gas exchange surface area. Lungs were demonstrated to be more developed at birth in ponies compared with Thoroughbreds. Thoroughbreds showed continued lung development after birth, a unique micromorphogenic postnatal development. Kidneys were developed equally in ponies and Thoroughbreds. This study has provided data on the baseline development of the equiune lung and kidney which can be used in further studies to examine whether the development of these organs is affected by specific illnesses. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
