| 不同周龄SPF级SD大鼠胰腺自发性病变的组织学观察 |
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| 引用本文： | 胡建廷,英永,邱波,王韶艳,屈卉锦,王凤乾.不同周龄SPF级SD大鼠胰腺自发性病变的组织学观察[J].动物医学进展,2012,33(8):65-68. |
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| 作者姓名： | 胡建廷 英永 邱波 王韶艳 屈卉锦 王凤乾 |
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| 作者单位： | 山东省医药工业研究所山东省化学药物重点试验室,山东济南,250033 |
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| 摘 要： | 研究不同周龄SPF级SD大鼠胰腺自发性病变的种类及其病变发生率,为药物安全性评价提供背景资料。收集3年安评试验中11、19、31周龄试验对照组大鼠胰腺制作病理切片,光学显微镜下观察SD大鼠胰腺病变的种类及组织形态学特点,并统计其病变发生率。结果显示,大鼠胰腺主要出现了以下病变:①单核细胞浸润:11周龄大鼠该病变的总体发生率为0.6%,其中雌性为0,雄性为1.25%;19周龄大鼠该病变的总体发生率为1.0%,其中雌性为1.0%,雄性为1.0%;31周龄大鼠该病变的总体发生率为1.0%,其中雌性为0,雄性为1.96%。②腺泡细胞空泡变性:11周龄大鼠未观察到该病变的发生;19周龄大鼠该病变的总体发生率为1.0%,其中雌性为0,雄性为2.0%;31周龄大鼠该病变的总体发生率为3%,其中雌性为2.1%,雄性为3.9%。③腺泡细胞萎缩、腺管增生:11周龄大鼠未观察到该病变的发生;19周龄大鼠该病变的总体发生率为0.5%,其中雌性为0,雄性为1.0%;31周龄大鼠该病变的总体发生率为3.0%,其中雌性为1.0%,雄性为4.9%。结果表明,SPF级大鼠胰腺可发生单核细胞浸润、腺泡细胞空泡变性、腺泡细胞萎缩及腺管增生等自发性病变,且病变发生率可随着年龄的增加而增加。
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| 关 键 词： | 胰腺 组织病理学 自发性疾病 SD大鼠 |
Histopathologic Observation on Spontaneous Lesions in Pancreas of Different Aged SPF SD Rats |
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| HU Jian-ting
,
YING Yong
,
QIU Bo
,
WANG Shao-yan
,
QU Hui-jin
,
WANG Feng-qian.Histopathologic Observation on Spontaneous Lesions in Pancreas of Different Aged SPF SD Rats[J].Progress In Veterinary Medicine,2012,33(8):65-68. |
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| Authors: | HU Jian-ting YING Yong QIU Bo WANG Shao-yan QU Hui-jin WANG Feng-qian |
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| Institution: | (Shandong Institute of Pharmaceutical Industry,Shandong Provincial Key Laboratory Of Chemical Drug,Jinan,Shandong,250033,China) |
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| Abstract: | To research the spontaneous lesions of pancreas in SD rats and establish the backgroud information of experimental animals for GLP,the HE-stained tissue sections of the pancreas in blank group of SD rats were collected.According to different ages,the histopathological feature of the pancreas was described with optical microscope,and the incidence was recorded.1.The total incidence of infiltration of mononuclear cells in 11 weeks old was 0.6%,the incidence in females was 0 and in males was 1.25%;The total incidence in 19 weeks old was 1%,the incidence in females was 1% and in males was 1.0%;The total incidence in 31 weeks old was 1.0%,the incidence in females was 0 and in males was 1.96%.2.The vacuolation of the acinar cells in 11 weeks old was not observed.The total incidence of vacuolation of the acinar cells in 19 weeks old was 1%,the incidence in females was 0 and in males was 2.0%;The total incidence in 31 weeks old was 3.0%,the incidence in females was 2.1% and in males was 3.9%.3.The atrophy of the acinar cells and ductal proliferation in 11 weeks old was not observed.The total incidence in 19 weeks old was 0.5%,the incidence in females was 0 and in males was 1.0%;The total incidence in 31 weeks old was 3%,the incidence in females was 1.0% and in males was 4.9%.The spontaneous lesions observed in pancreas of SD rats included infiltration of mononuclear cells,vacuolation of the acinar cells and atrophy of the acinar cells and ductal proliferation.The incidence of spontaneous lesions above mentioned was increased with increasing age. |
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| Keywords: | pancreas histopathology spontaneous lesion SD rat |
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