Some Comparative Aspects of the Pharmacokinetics of Tylosin in Buffaloes and Cattle |
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| Authors: | Saurit AR Rubio M Baroni E San Andrés M Sánchez S Boggio JC |
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| Institution: | (1) Facultad de Ciencias Veterinarias, Cátedra de Farmacología, P. Kreder 2805, Esperanza, C.P. 3080, Santa Fe, Argentina;(2) Cátedra de Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain;(3) Analytical Pharmacology Laboratory, Moredun Research Institute, Penicuik, UK;(4) Facultad de Ciencias Veterinarias, Cátedra de Farmacología, P. Kreder 2805, Esperanza, C.P. 3080, Santa Fe, Argentina |
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| Abstract: | The pharmacokinetics of tylosin were compared in cattle (Bos taurus) and buffaloes (Bubalus bubalis). Six animals received each a single dose of 10 mg/kg of tylosin tartrate by the intramuscular route. The serum concentration (C
max) and the volume of distribution (V
d) presented significant differences between the two species. C
max was 0.40 ± 0.046 µg/ml for buffaloes and 0.64 ± 0.068 µg/ml for cattle. V
d was 1.91 ± 0.12 L/kg and 1.33 ± 0.09 L/kg for buffaloes and cattle, respectively. However, as the present study did not show considerable differences in the pharmacokinetics of tylosin in buffaloes and cattle, similar dosage regimes of this drug can be recommended for both species. |
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| Keywords: | buffalo calves cattle dosage pharmacokinetics species tylosin |
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