| 二氟沙星对3种海洋弧菌的抗菌后效应研究 |
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| 引用本文： | 盖春蕾,李健,刘淇,王群.二氟沙星对3种海洋弧菌的抗菌后效应研究[J].海洋水产研究,2008,29(2):97-101. |
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| 作者姓名： | 盖春蕾 李健 刘淇 王群 |
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| 作者单位： | 1. 上海水产大学生命学院,200090;农业部海洋渔业资源可持续利用重点开放实验室,中国水产科学研究院黄海水产研究所,青岛,266071
2. 上海水产大学生命学院,200090 |
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| 基金项目： | 科技部社会公益研究项目 |
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| 摘 要： | 采用试管二倍稀释法测定二氟沙星对鳗弧菌W-1、副溶血弧菌1614和溶藻弧菌1833的最小抑菌浓度(MIC);采用菌落计数法测定二氟沙星对鳗弧菌、副溶血弧菌和溶藻弧菌的抗菌后效应(PAE)。结果显示,二氟沙星在1×MIC、2×MIC和4×MIC浓度时,对鳗弧菌W-1、副溶血弧菌1614和溶藻弧菌1833的PAE分别为:0·64、1·09和2·16h;0·74、1·73和2·64;0·54、1·08和2·05h。二氟沙星对这3种弧菌具有明显的抗菌后效应,并且随着二氟沙星浓度的增加,抗菌后效应的时间也明显延长。
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| 关 键 词： | 二氟沙星 鳗弧菌 副溶血弧菌 溶藻弧菌 抗菌后效应 |
| 文章编号： | 1000-7075(2008)02-0097-05 |
| 修稿时间： | 2007年1月5日 |
Postantibiotic effects of difloxacin on three marine Vibrio strains |
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| GAI Chun-lei,LI Jian,LIU Qi,WANG Qun.Postantibiotic effects of difloxacin on three marine Vibrio strains[J].Marine Fisheries Research,2008,29(2):97-101. |
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| Authors: | GAI Chun-lei LI Jian LIU Qi WANG Qun |
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| Abstract: | The minimal inhibitory concentrations (MIC) of difloxacin against Vibrio anguillarum W-1, V. parahaemolyticus 1614 and V. alginolyticus 1833 were determined by twofold broth macrodilution method, and the postantibiotic effects (PAE) of difloxacin against the three Vibrio strains were determined by colony counting. It was shown that, at the concentrations of 1MIC, 2MIC and 4MIC, the PAE of difloxacin against Vibrio anguillarum W-1, V.parahaemolyticus 1614, V. alginolyticus 1833 was 0.64h, 1.09h and 2.16h; 0.74h, 1.73h and 2.64h ; 0.54h,1.08h and 2.05h, respectively. There were significant PAE of difloxacin against the three Vibrio strains, and the time of PAE was prolonged as the concentration of difloxacin increased. |
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| Keywords: | Difloxacin Vibrio anguillarum Vibrio parahaemolyticus Vibrio alginolyticus Postantibiotic effect (PAE) |
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