| 猪繁殖与呼吸综合征病毒不同毒株感染对猪外周血免疫细胞含量的影响 |
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| 引用本文： | 万博,乔松林,张改平,叶晓敏,肖志军.猪繁殖与呼吸综合征病毒不同毒株感染对猪外周血免疫细胞含量的影响[J].畜牧兽医学报,2009,40(11). |
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| 作者姓名： | 万博 乔松林 张改平 叶晓敏 肖志军 |
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| 作者单位： | 1. 河南省农业科学院,河南省动物免疫学重点实验室农业部动物免疫学重点开放实验室,郑州,450002
2. 郑州牧业工程高等专科学校,郑州,450002 |
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| 基金项目： | 国家自然科学基金重点项目，河南省重大科技攻关计划项目 |
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| 摘 要： | 采用猪繁殖与呼吸综合征病毒(PRRSV)变异株HN07-01和经典美洲株BJ-4人工感染2月龄仔猪,通过观察发病情况、检测外周血免疫细胞和PRRSV特异血清抗体水平,研究了不同毒株PRRSV的致病特性.结果表明:PRRSV变异株感染后能够引起高热症状;变异株HN07-01株感染后引起的外周血各类免疫细胞下降速度和下降程度显著高于BJ-4株.提示PRRSV变异株引起机体的免疫抑制明显强于BJ-4株;PRRSV特异血清抗体结果表明:变异株和BJ-4株均能快速诱导机体产生抗体.
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| 关 键 词： | 猪繁殖与呼吸综合征 白细胞 抗体 体温 |
The Effects of Different PRRSV Strains Infection on the Peripheral Blood Immune Cells of Swine |
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| WAN Bo,QIAO Song-lin,ZHANG Gai-ping,YE Xiao-min,XIAO Zhi-jun.The Effects of Different PRRSV Strains Infection on the Peripheral Blood Immune Cells of Swine[J].Acta Veterinaria et Zootechnica Sinica,2009,40(11). |
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| Authors: | WAN Bo QIAO Song-lin ZHANG Gai-ping YE Xiao-min XIAO Zhi-jun |
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| Abstract: | In this study, 2-month-old piglets were inoculated with porcine reproductive and respir-atory syndrome virus (PRRSV) variant strain HN07-01 and classical strain BJ-4,respectively. To investigate the pathogenicity of different PRRSV strains, the clinical symptoms was observed and the peripheral blood immune cells and serum PRRSV-specific antibodies were detected. The re-sults showed that the high fever was induced by PRRSV variant strain. Peripheral blood immune cells in HN07-01 infected piglets decreased significantly than that in BJ-4 strain, which indicated the severer immune suppression induced by PRRSV variant. The result of PRRSV-specific anti-body detection showed that both the PRRSV variant and BJ-4 strain can induce antibody quickly. |
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| Keywords: | porcine reproductive and respiratory syndrome virus white cells antibodies temper-ature |
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