| 纳米乳在药剂学中的研究进展及其应用 |
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| 引用本文： | 胡宏伟,李剑勇,吴培星,周绪正,张继瑜.纳米乳在药剂学中的研究进展及其应用[J].湖北农业科学,2009,48(3). |
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| 作者姓名： | 胡宏伟 李剑勇 吴培星 周绪正 张继瑜 |
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| 作者单位： | 1. 中国农业科学院兰州畜牧与兽药研究所新兽药工程重点开放实验室,兰州,730050;甘肃农业大学动物医学院,兰州,730070
2. 中国农业科学院兰州畜牧与兽药研究所新兽药工程重点开放实验室,兰州,730050 |
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| 基金项目： | 国家高技术研究发展计划(863计划)重大项目，中央级公益性科研院所基本科研业务费专项资金项目 |
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| 摘 要： | 综述纳米乳作为新型药物载体的优势,形成纳米乳的各组分发挥的作用以及不同给药途径在药剂学方面的应用状况.查阅大量近年来国内外的相关文献并进行归纳、总结.结果表明,纳米乳在透皮给药、口服给药、黏膜给药、注射给药等多个给药途径中较之普通乳剂有明显的优势.纳米乳作为一种新型药物载体系统具有对难溶性药物强大的增溶作用,还具有明显的缓释作用、靶向性及较高的生物利用度等优点,在药剂学领域有广阔的应用前景.
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| 关 键 词： | 纳米乳 表面活性剂 给药系统 生物利用度 |
Research Progress on Application of Nanoemulsions in Pharmaceutics |
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| HU Hong-wei,LI Jian-yong,WU Pei-xing,ZHOU Xu-zheng,ZHANG Ji-yu.Research Progress on Application of Nanoemulsions in Pharmaceutics[J].Hubei Agricultural Sciences,2009,48(3). |
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| Authors: | HU Hong-wei LI Jian-yong WU Pei-xing ZHOU Xu-zheng ZHANG Ji-yu |
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| Institution: | 1. Key Laboratary for New Animal Drug of Lanzhou Institute of Animal Science and Veterinary Pharmaceutics;Chinese Academy of Agricultural Sciences;Lanzhou 730050;China;2. College of Veterinary Medicine;Gansu Agricultural University;Lanzhou 730070;China |
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| Abstract: | The advantages of nanoemulsion as a novel vehicle of the drug delivery system, the roles of the ingredients and the application of various methods of administration in pharmaceutics were systematically reviewed. The application of nanoemulsions in drug delivery systems including transdermal, mucosal, oral and injection delivery systems was better than ordinary emulsions. Nanoemulsions, with a very good prospect in pharmaceutics in the future, had many good characters such as good solubilization to indissolv... |
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| Keywords: | nanoemulsion surfactant delivery system bioavailability |
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