Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives |
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| Authors: | Chamberlain Samuel R Menzies Lara Hampshire Adam Suckling John Fineberg Naomi A del Campo Natalia Aitken Mike Craig Kevin Owen Adrian M Bullmore Edward T Robbins Trevor W Sahakian Barbara J |
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| Institution: | Department of Psychiatry, University of Cambridge, Addenbrooke's Hospital, Box 189, Cambridge CB2 0QQ, UK. srchamb@gmail.com |
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| Abstract: | Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative feedback (reversal learning). We identified abnormally reduced activation of several cortical regions, including the lateral orbitofrontal cortex, during reversal learning in OCD patients and their clinically unaffected close relatives, supporting the existence of an underlying previously undiscovered endophenotype for this disorder. |
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