| γ-氨基丁酸对热应激大鼠新生子代的发育及抗氧化力的影响 |
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| 引用本文： | 范志勇,邓近平,杨玲媛,朱立涛,杨丹丹.γ-氨基丁酸对热应激大鼠新生子代的发育及抗氧化力的影响[J].中国农学通报,2012,28(11):89-92. |
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| 作者姓名： | 范志勇 邓近平 杨玲媛 朱立涛 杨丹丹 |
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| 作者单位： | 1. 湖南农业大学饲料安全与高效利用教育部工程研究中心,长沙410128;湖南农业大学国家植物功能成分利用工程技术研究中心,长沙410128;湖南农业大学动物科学技术学院动物营养研究所,长沙410128
2. 湖南农业大学饲料安全与高效利用教育部工程研究中心,长沙410128;湖南农业大学动物科学技术学院动物营养研究所,长沙410128 |
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| 基金项目： | 国家自然科学基金“GABA对母猪热应激的营养调控机理研究”（30700579）; 湖南省高校科技创新团队资助计划“畜禽应激生理与营养调控”; 湖南农业大学人才引进资助项目“γ-氨基丁酸及其受体代谢对母猪的生殖调控作用机理研究”（11YJ01）;湖南农业大学青年科学基金项目“γ-氨基丁酸对热应激大鼠子代的生长发育和抗氧化能力的影响”（08QN02） |
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| 摘 要： | 为研究日粮中添加γ-氨基丁酸对热应激大鼠子代发育和抗氧化功能的影响，选用90日龄的Sprague-Dawley大鼠52只(雌性大鼠39只，雄性13只)进行试验，交配后27只受孕雌鼠随机分为三组，正常对照组，热应激组和GABA热应激组，仔鼠出生后1天，测定发育指标和肝脏抗氧化指标。结果显示，与正常对照组相比，热应激组新生雌鼠和雄鼠的尾长均显著降低(P＜0.01)；新生大鼠的肝脏谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)活性有所降低，丙二醛(MDA)含量有所升高，但差异均不显著。与热应激组相比，GABA热应激组新生雌鼠(P＜0.01)和雄鼠(P＜0.05)的尾长均显著提高；新生大鼠的肝脏MDA含量有所降低，GSH-Px、SOD活性有所升高，但差异均不显著。结果提示GABA一定程度上可改善孕期热应激条件下新生大鼠的抗应激能力。
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| 关 键 词： | FA旱地龙 FA旱地龙 盐渍化棉田 施用量 土壤改良 |
| 收稿时间： | 2011/9/18 0:00:00 |
| 修稿时间： | 2011/11/4 0:00:00 |
Effects of γ-aminobutyric Acid on Development and Antioxidant Ability of Neonates of Heat-Stressed Rats |
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| Fan Zhiyong
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Deng Jinping
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Yang Lingyuan
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Zhu Litao
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Yang Dandan.Effects of γ-aminobutyric Acid on Development and Antioxidant Ability of Neonates of Heat-Stressed Rats[J].Chinese Agricultural Science Bulletin,2012,28(11):89-92. |
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| Authors: | Fan Zhiyong Deng Jinping Yang Lingyuan Zhu Litao Yang Dandan |
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| Institution: | 1 Engineering Research Center for Feed Safety and Efficient Utilization of Ministry of Education Hunan Agricultural University,Changsha 410128;2 National Research center of Engineering Technology for Utilization of Functional Ingredients from Botanicals Hunan Agricultural University,Changsha 410128;3 Institute of Animal Nutrition Hunan Agricultural University,Changsha 410128) |
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| Abstract: | The effects of dietary γ-aminobutyric acid （GABA） on development and antioxidant ability of neonates of heat-stressed rats were investigated.52 rats aged 90 days,39 females and 13 males,were the experimental subjects.27 pregnant rats were randomly divided into three groups after mating：the control group,the heat-stressed group and the GABA heat-stressed group.The development indiced and hepatic antioxidant indices of 1 d neonates were measured.The results showed that tail lengths of the female and male neonates from the heat-stressed group fed with basal diet were both decreased very significantly （P 0.01） compared with that of the control group,while the hepatic malondialdehyde （MDA） contents increased slightly,activities of glutathione peroxidase （GSH-Px） and superoxide dismutase （SOD） decreased slightly.Compared with the heat-stressed pregnant rats fed with basal diet,tail lengths of the female （P 0.01）and male （P 0.05） neonates from the GABA group,but MDA contents decreased slightly and activities of GSH-Px,SOD increased slightly.The results indicated that GABA could improve anti-heat-stress ability in neonatal rats under heat stress condition during pregnancy. |
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| Keywords: | γ-aminobutyric acid heat stress neonatal rats development antioxidant ability |
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