Progress in RNA-binding protein HuR and its roles in development of hepatocellular carcinoma |
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| Authors: | SU Ying JIN Chun SUN Su-min LI Zhang-hao XIA Si-wei ZHANG Zi-li ZHANG Feng SHAO Jiang-juan ZHENG Shi-zhong |
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| Institution: | 1.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine， Nanjing 210023， China;2.Jiangsu Key Laboratory of Substance of Chinese Medicine, Nanjing University of Chinese Medicine， Nanjing 210023， China;3.State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine， Nanjing 210023， China |
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| Abstract: | RNA-binding proteins （RBP） are molecules with a variety of biological functions discovered in recent years. Among them， HuR is an important RBP， widely expressed in various tissues of the body， and is a member of the Hu/embryonic lethal abnormal vision （ELAV） protein family. It mainly affects the expression levels of target genes in the cells by regulating the stability and/or translation efficiency of the mRNA of the genes， thus participating in the regulation of cell life activities. In recent years， more and more studies on HuR have revealed its important role in inflammation and cancer. This review summarizes the functions of HuR and probes into the regulation of HuR functions. In addition， the roles of HuR in the occurrence and development of hepatocellular carcinoma （HCC） are also discussed， which provides important information for exploring the pathogenesis， biomarkers and therapeutic targets of HCC. |
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| Keywords: | RNA-binding proteins HuR protein Hepatocellular carcinoma |
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