| 抗菌药物的抗菌后效应研究进展及其意义 |
| |
| 引用本文： | 王丽平,江善祥,史晓丽.抗菌药物的抗菌后效应研究进展及其意义[J].动物医学进展,2003,24(5):39-41. |
| |
| 作者姓名： | 王丽平 江善祥 史晓丽 |
| |
| 作者单位： | 南京农业大学动物医学院药理组,江苏南京,210095 |
| |
| 摘 要： | 抗菌药的抗菌后效应 (PAE)是新近提出的一个重要概念 ,它是细菌对抗微生物药敏感性的结构特征性指标 ,几乎是所有抗菌药物的一种性质。PAE以时间的长短来表示 ,可作为重要的药效学参数 ,可作为设计给药方案的参考依据 ,并为临床调整用药间隔提供理论基础 ,且对给药方案中存在的疗效、不良反应、费用和方便性等问题提供了很好的解决办法。该参数能较大程度地完善药效动力学评价指标 ,全面反映药物、细菌及宿主三者之间的关系 ,为临床中抗菌药物的合理使用提供了一定的思路
|
| 关 键 词： | 抗菌后效应 药效学参数 合理用药 |
| 文章编号： | 1007-5038(2003)05-0039-03 |
| 修稿时间： | 2003年3月17日 |
The Progress and Value of Postantibiotic Effect in Antimicrobial Agent |
| |
| WANG li ping,JIANG Shan xiang,SHI Xiao li.The Progress and Value of Postantibiotic Effect in Antimicrobial Agent[J].Progress In Veterinary Medicine,2003,24(5):39-41. |
| |
| Authors: | WANG li ping JIANG Shan xiang SHI Xiao li |
| |
| Abstract: | Postantibiotic effect(PAE) is a new concept in antimicrobial pharmacodynamic effect and is defined as the persisting suppression of bacterial growth after a limited exposure to an antimicrobial agent, so the value of PAE is usually defined with time. PAE is an intrinsic characteristic of each antimicrobial agent,and has been shown to exist both in vitro and in vivo. The PAE was a well established pharmacodynamic parameter and well reflect the relationship among drug, bacteria and host. The knowledge of the duration of PAE may be of important clinical interest in establishing dosing schedules for the treatment of infections, thus the PAE of antimicrobial agent on bacteria provide additional,valuable information towards the rational use of a drug in clinical practice. |
| |
| Keywords: | postantibiotic effect pharmacodynamic parameter rational use |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
