Nephrotoxicity and hepatotoxicity in calves apparently caused by experimental feeding withNarthecium ossifragum |
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| Authors: | A Flåøyen B Bratberg A Frøslie H Grønstøl |
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| Institution: | (1) Department of Reproduction and Forensic Medicine, Norwegian College of Veterinary Medicine, POB 8146 Dep., N-0033 Oslo;(2) Department of Large Animal Clinical Sciences, Norwegian College of Veterinary Medicine, POB 8146 Dep., N-0033 Oslo;(3) Central Veterinary Laboratory, POB 8156 Dep., N-0033 Oslo, Norway |
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| Abstract: | Seven calves were fed a mixture of bog plants containing 15 g (wet matter)Narthecium ossifragum per kg live weight for two consecutive days. Their serum creatinine, urea and magnesium concentrations increased, whereas the serum calcium concentration decreased. Histopathological examination of the kidneys of the 5 calves that were killed revealed tubular epithelial cell degeneration and necrosis. There were signs of liver dysfunction in all the calves including increased aspartate aminotransferase (ASAT), glutamate dehydrogenase (GLDH) and  -glutamyltransferase activities.All the calves refused to ingestN. ossifragum after 2 days feeding, and their appetite for hay and concentrate was also reduced. It can be concluded thatN. ossifragum is nephrotoxic and hepatotoxic to calves.Abbreviations ALP
alkaline phosphatase
- ASAT
aspartate aminotransferase
-  -HBA
-hydroxybutyric acid
- CK
creatine kinase
- d.m.
dry matter
- -GT
-glutamyltransferase
- GFR
glomerular filtration rate
- GLDH
glutamate dehydrogenase
- MCV
mean cell volume
- RBC
red blood cells
- SEM
standard error of the mean
- WBC
white blood cells
- w.m.
wet matter |
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| Keywords: | calves kidney liver Narthecium ossifragum toxicity |
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