|
|||||
|
|
Antifungal bioactivity of 6-bromo-4-ethoxyethylthio quinazoline |
|
| Authors: | Fang Liu Yinjiu Huang |
| Institution: | a Department of Pharmacy, Bengbu Medical College, Anhui Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu, Anhui, PR China b Department of Bioscience, Bengbu Medical College, Bengbu, Anhui, PR China c Research and Development Centre for Fine Chemicals, Guizhou University, Guiyang, Guizhou, PR China |
| Abstract: | In order to create novel potent antifungal agents, the antifungal effects of 6-bromo-4-ethoxyethylthio quinazoline on plant pathogenic fungi were evaluated by mycelial growth rate method. The bioassay results showed that title compound possesses high antifungal activities on fungi with EC50 values ranging from 17.47 to 70.79 μg/mL. The mechanism of action of 6-bromo-4-ethoxyethylthio quinazoline against fungi was studied in Gibberella zeae model. After treated with title compound at 100 μg/mL for 12 h, the mycelial reducing sugar, chitosan, soluble protein and pyruvate content, chitinase activity showed declining tendency. |
| Keywords: | 6-Bromo-4-ethoxyethylthio quinazoline Antifungal bioactivity Mechanism of action Gibberella zeae |
| 本文献已被 ScienceDirect 等数据库收录！ | |