| 2009甲型H1N1流感病毒的研究综述(英文) |
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| 引用本文： | 刘超,刘连芬,王波,李付国,姜乃化,曾晓辉.2009甲型H1N1流感病毒的研究综述(英文)[J].农业科学与技术,2012(2):424-427. |
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| 作者姓名： | 刘超 刘连芬 王波 李付国 姜乃化 曾晓辉 |
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| 作者单位： | 聊城大学生命科学学院;烟台万华聚氨酯股份有限公司;江西省井冈山国家自然保护区管理局 |
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| 基金项目： | Supported by National Natural Science Foundation of China(31070619)~~ |
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| 摘 要： | 目的]介绍2009甲型H1N1流感病毒的研究进展。方法]从病毒的分类与宿主,病毒学,分子特征及疫苗等方面简要介绍了2009甲型H1N1流感病毒。结果]2009年4月初出现的一种新型甲型(H1N1)流感病毒通过人-人传播迅速蔓延全球,该病毒包含一组新的基因片段,已知的最接近的前体为在猪体内发现的病毒。该病毒似乎保留着重新感染猪的潜力从而可能继续与猪源病毒发生重组。所有已注册的2009甲型流感疫苗均在对志愿者的临床试验中测试了安全性和免疫原性,发现所有疫苗都是安全的,并且单剂量的疫苗给药后引起保护性抗体反应。结论]为进一步研究2009甲型H1N1流感病毒提供依据。
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| 关 键 词： | 猪源流感病毒 甲型H1N1流感 基因重排 血凝素 疫苗 |
A Review on 2009 Influenza A Virus |
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| Institution: | Chao LIU1, Lianfen LIU1, Bo WANG1, Fuguo LI2,Naihua JIANG2, Xiaohui ZHENG3 1. School of Life Sciences, Liaocheng University, Liaocheng 252059, China; 2. Yantai Wanhua Polyurethanes Co., Ltd., Yantai 264005, China; 3. Administration Bureau of Jingangshan National Nature Reserve, Jinggangshan 343600, China |
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| Abstract: | Objective] The paper was to introduce the research progress of 2009 influenza A virus. Method] 2009 influenza A virus was introduced from the aspects of classification and host, virology, molecular characteristics and vaccine. Result] A novel influenza A/H1N1 virus emerged in early April 2009 quickly spread worldwide through human-to-human transmission. The virus contained a group of novel gene segments, the nearest known precursor was the virus found in swine. The virus appeared to retain the potential to infect swine again and thus continued reassort with swine viruses. All registered 2009 influenza A vaccines were tested for safety and immunogenicity in clinical trials on human volunteers, and all vaccines were found to be safe, single dose of vaccine could cause protective antibody responses. Conclusion] The paper provided basis for further study on 2009 influenza A virus. |
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| Keywords: | Swine-origin influenza virus Influenza A H1N1 Gene reassortment Hemagglutinin Vaccine |
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