| 盐酸小檗碱在鸡体内的药动学研究 |
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| 引用本文： | 高海鹏,邱银生.盐酸小檗碱在鸡体内的药动学研究[J].中国兽药杂志,2009,43(3):31-34. |
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| 作者姓名： | 高海鹏 邱银生 |
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| 作者单位： | 武汉工业学院饲料科学系,湖北省饲料工程技术研究中心,武汉,430023 |
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| 摘 要： | 探讨盐酸小檗碱在鸡体内的药动学特征。鸡以3mg／kg和50mg／kg剂量静脉注射和口服给药，采用HPLC法测定血浆中盐酸小檗碱的质量浓度。血药浓度-时间数据经DAS药代动力学分析软件处理，计算出药动学参数。结果表明：盐酸小檗碱静脉注射药时曲线符合三室开放模型，主要药动学参数分别为：t1／2β为（0．41±0．24）h，t1／2γ为（3．66±1．06）h，Vc为（25．49±21．77）L·kg^-1，CL为（43．20±16．21）L·h^-1·kg^-1，AUC为（78．92±30．58）μg·L^-1·h。盐酸小檗碱口服给药的药时曲线符合二室开放模型，主要药动学参数分别为：t1／2α为（1．87±0．76）h，t1／2β为（4．18±3.14）h，t1／2ka为（0．89±0．46）h，Tmax为（2．64±0．63）h，Cmax为（4．09±0．11）μg·L^-1，AUC为（26．18±10．73）μg·L^-1·h，绝对生物利用度为2．03％。鸡口服盐酸小檗碱的生物利用度低，消除较快。
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| 关 键 词： | 盐酸小檗碱 鸡 HPLC 药动学 |
| 收稿时间： | 2008/9/22 0:00:00 |
| 修稿时间： | 2008/10/26 0:00:00 |
Pharmacokinetic Study of Berberine Hydrochloride in chickens |
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| gaohaipeng and.Pharmacokinetic Study of Berberine Hydrochloride in chickens[J].Chinese Journal of Veterinary Drug,2009,43(3):31-34. |
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| Authors: | gaohaipeng and |
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| Institution: | Wuhan Poly-technological University, |
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| Abstract: | This article investigated the pharmacokinetics of berberine hydrochloride in chickens. The plasma concentration of berberine was determined by HPLC. The plasma concentration - time data of berberine hydrochlo- ride was analyzed by Drug and Statistics （DAS）. Following intravenous administration （ 3 mg· kg^- 1 ） , the drug concentration- time data was best described by a three -compartment open model , t1/2β, t1/2γ, Vc, CL and AUC were （0.41 ±0.24） h, （3.66 ± 1.06） h , （25.49 ±21.77） L·kg^-1, （43.20 ± 16.21） L·h^-1·kg^-1 and （78.92 ± 30.58）μg·L^-1· h respectively. The drug concentration- time data was best described bya two - compartment open model after oral administration of 50 mg·kg^-1, t1/2α, t1/2β ,t1/2ka,Tmax,Cmax and AUC were （1.87 ±0.76） h ,（4.18 ±3.14） h,（0.89 ±0.46） h,（2.64 ±0.63） h,（4.09 ±0.11）μg·L^-1 and （26.18 ± 10.73 ） μg·L^-1·h respectively. The absolute bioavailability was 2.03 % after oral administration. Berberine hydrochloride had a low rate of bioavailability by oral administration, and its elimination was fast. |
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| Keywords: | HPLC |
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