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| 新型饲料添加剂喹烯酮磺酸盐特殊毒理学研究 | |
| 引用本文： | 赵凤舞,张铎,尚若锋,王学红,廖健雄,李贵玉,刘宇,郝宝成,陶蕾.新型饲料添加剂喹烯酮磺酸盐特殊毒理学研究[J].中兽医医药杂志,2013,32(3):13-17. |
| 作者姓名： | 赵凤舞 张铎 尚若锋 王学红 廖健雄 李贵玉 刘宇 郝宝成 陶蕾 |
| 作者单位： | 1. 兰州职业技术学院,甘肃兰州,730070 2. 中国农业科学院兰州畜牧与兽药研究所,甘肃兰州,730050 3. 浙江海正药业股份有限公司,浙江台州,318000 |
| 摘 要： | 采用Ames试验、微核试验、精子畸形试验等,考察新型饲料添加剂喹烯酮磺酸盐的特殊毒理学特征。Ames试验结果表明,喹烯酮磺酸盐对鼠伤寒沙门氏菌TA98和TA100两个标准菌株均产生诱变性,并且在加入S9代谢活化系统后回复突变菌落数明显减少;小鼠体内微核试验和精子畸形试验结果均为阴性。 |
| 关 键 词： | 喹烯酮 喹烯酮磺酸盐 特殊毒理学 |
Study on the special-toxicology of feed additive Quinocetonesulfonates |
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| ZHAO Feng-wu,ZHANG Duo,SHANG Ruo-feng,WANG Xue-hong,LIAO Jian-xiong,LI Gui-yu,LIU Yu,HAO Bao-cheng,TAO Lei,LIANG Jian-ping.Study on the special-toxicology of feed additive Quinocetonesulfonates[J].Journal of Traditional Chinese Veterinary Medicine,2013,32(3):13-17. | |
| Authors: | ZHAO Feng-wu ZHANG Duo SHANG Ruo-feng WANG Xue-hong LIAO Jian-xiong LI Gui-yu LIU Yu HAO Bao-cheng TAO Lei LIANG Jian-ping |
| Institution: | 1.Lanzhou Vocational Technical College,Lanzhou Gansu 730070;2.Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences,Lanzhou Gansu 730050;3.Zhejiang Hisun Pharmaceutical Co.Ltd,Taizhou Zhejiang 318000,China) |
| Abstract: | Quinocetone derivatives such as Quinocetonesulfonates are added to pig or chicken feed as antibacterial and grow promoting feed additives.In order to evaluate their safety,the special-toxicology of the Quinocetonesulfonates was studied with Ames test,micronucleus assay and sperm deformity test.Ames test showed that Quinocetonesulfonates could induce mutagenesis in Salmonella typhimurium TA98 and TA100 with or without S9 activate system.While the micronucleus assay and sperm deformity test present negative results. |
| Keywords: | Quinocetone Quinocetonesulfonates special-toxicology |
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