Environmental degradation of the insect growth regulator methoprene: V. Metabolism by houseflies and mosquitoes |
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| Authors: | Gary B Quistad Luana E Staiger David A Schooley |
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| Institution: | Zoecon Corporation Research Laboratory, 975 California Avenue, Palo Alto, California 94304 USA |
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| Abstract: | The metabolism of methoprene (I, isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate, trademark Altosid) was investigated in larval mosquitoes and houseflies. The most abundant primary metabolite in third- and fourth-instar Aedes and fourth-instar Culex larvae was the hydroxy ester while the hydroxy acid predominated in third-instar Musca larvae. Biological isomerization of the double bond at C-2 in I (i.e., conversion of (E) to (Z)) was an effective mode of insect detoxication, but these dipterans apparently cannot isomerize the (2Z) isomer of I to methoprene. In general, piperonyl butoxide and triorthocresyl phosphate slightly increased the morphogenetic activity of I in these insects. |
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