| 二氢吡啶海藻酸钙凝胶小球的制备工艺 |
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| 引用本文： | 冯仁蕊,欧阳五庆,赵元.二氢吡啶海藻酸钙凝胶小球的制备工艺[J].西北农业学报,2009,18(4):81-84,97. |
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| 作者姓名： | 冯仁蕊 欧阳五庆 赵元 |
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| 作者单位： | 西北农林科技大学,动物医学院,陕西杨陵,712100 |
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| 摘 要： | 研究二氢吡啶海藻酸钙凝胶小球的制备工艺和最优处方.以海藻酸钠为基质材料,采用滴制法制备海藻酸钙凝胶小球,以二氢吡啶的包封率和载药量作为制备工艺优化指标,设计正交试验优选最佳处方;测定最佳处方所制制剂的包封率(Encapsulation efficiency,EE)和载药量(Drug loading,LD)并与原料药比较体外释放作用.最优处方为海藻酸钠浓度1.5%,海藻酸钠与二氢吡啶质量比1:2,氯化钙浓度0.10 mol/L;EE和LD值分别为81.16%,48.20%,与原料药相比缓释性较好,且具有良好的溶胀性能.本法工艺简单、可行、稳定,重现性好.
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| 关 键 词： | 二氢吡啶 海藻酸钙 凝胶小球 制备工艺 |
| 收稿时间： | 2009/1/7 0:00:00 |
| 修稿时间： | 2009/3/11 0:00:00 |
Preparation Technology of Diludine Calcium Alginate Gel Beads |
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| FENG Renrui,OUYANG Wuqing and ZHAO Yuan.Preparation Technology of Diludine Calcium Alginate Gel Beads[J].Acta Agriculturae Boreali-occidentalis Sinica,2009,18(4):81-84,97. |
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| Authors: | FENG Renrui OUYANG Wuqing and ZHAO Yuan |
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| Institution: | College of Veterinary Medicine, Northwest A & F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A & F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A & F University, Yangling Shaanxi 712100, China |
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| Abstract: | This research is to study the preparation technology and optimal formulation of diludine calcium alginate gel beads.Diludine calcium alginate gel beads were prepared by droplet method with sodium alginate as matrix material.The orthogonal experiment was carried out with encapsulation efficiency (EE) and drug loading (LD) as indexes to optimize the optimal form ulation of the calcium alginate gelbeads.The release efficiency in vitro and drug loading amount for the optimized for mulation were determined, and the optimized for mulation was com pared with crude drug in respect of the in vitro drug release behavior.The result showed that the optimal form ulation was as follows: 1.5% Na-alginate and 0.10 mol/L CaCl2 with the ratio of Na-alginate: diludine at 1:2.The EE and LD were 81.16% and 48.20%, respectively, and the slow-release was better as compared with that of the crude drug.The gelbeads have excellernt swelling behaviour.The preparation procedure is simple, feasible, stable and reproducible. |
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| Keywords: | Diludine Calcium alginate Gelbeads Preparation technology |
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