| 复方天门冬多糖注射液的靶动物（鸡）安全性试验 |
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| 引用本文： | 胡国明,胡庭俊,邢小勇,温峰琴,胡永浩.复方天门冬多糖注射液的靶动物（鸡）安全性试验[J].广西农业科学,2014,45(8):1481-1485. |
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| 作者姓名： | 胡国明 胡庭俊 邢小勇 温峰琴 胡永浩 |
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| 作者单位： | 1. 甘肃农业大学动物医学院,兰州,730070
2. 广西大学动物科学技术学院,南宁,530005 |
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| 基金项目： | 广西自然科学基金重点项目 |
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| 摘 要： | 【目的】研究复方天门冬多糖注射液对靶动物（鸡）的安全性,为其临床用药提供参考依据。【方法】以鸡为靶动物进行肌肉注射给药,然后对试验鸡的临床症状、体重变化、饲料报酬及血液常规指标、血液生化指标等进行安全性评估,以确定受试药物的最大耐受剂量或耐受范围。【结果】鸡只注射复方天门冬多糖注射液后,能明显增加其日均增重和降低饲料报酬,促进鸡体生长发育,尤其以5倍剂量组（10.0 mL/kg）的效果最佳;在血液常规指标方面,除血小板数呈明显降低趋势外,白细胞数、红细胞数、红细胞压积、血红蛋白含量等指标的变化不明显,且不同处理组间的差异不显著（P＆gt;0.05）;在血液生化指标方面,注射复方天门冬多糖注射液后1周内各项生化指标呈无规律的升高或降低变化趋势,至给药后第14 d（31日龄）,则以5倍剂量组的各项指标较接近于正常水平。【结论】复方天门冬多糖注射液是一种有效的免疫增强剂,能促进鸡体生长发育,且在实际生产应用中具有较高的安全性,其在靶动物（鸡）上的最大耐受剂量为10.0 mL/kg。
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| 关 键 词： | 复方天门冬多糖注射液 靶动物(鸡) 体重 饲料报酬 血常规指标 血液生化指标 安全性 |
Safety test of compound Asparagus cochinchinensis polysaccharide injection to target animals (chickens) |
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| HU Guo-ming,HU Ting-jun,XING Xiao-yong,WEN Feng-qin,HU Yong-hao.Safety test of compound Asparagus cochinchinensis polysaccharide injection to target animals (chickens)[J].Guangxi Agricultural Sciences,2014,45(8):1481-1485. |
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| Authors: | HU Guo-ming HU Ting-jun XING Xiao-yong WEN Feng-qin HU Yong-hao |
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| Institution: | HU Guo-ming, HU Ting-jun, XING Xiao-yong, WEN Feng-qin, HU Yong-hao (1.College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China; 2.Guangxi University, Nanning 530005, China) |
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| Abstract: | 【Objective】Safety of compound Asparagus cochinchinensis polysaccharide injection to target animals（chickens） was studied to provide references for clinical use. 【Method】The clinical symptoms, weight change, feed conversion,indicators of blood and blood biochemical indicators were observed and analyzed to determine the maximum tolerance dose or tolerance range. 【Result】When the chicken was injected by compound Asparagus cochinchinensis polysaccharide, its average daily weight was markedly increased and feed conversion value was lowered. The injection also promoted the growth and development, and especially 5-fold dose（10.0 mL/kg） was the best. Regarding routine blood indicators, the changes of WBC, red blood cell count, hematocrit, hemoglobin and other indicators were not obvious except that the platelet count decreased significantly. The difference among the different treatments was not significant. As to the blood biochemical indicators, the biochemical indicators showed erratic increase or decrease trends within a week after injecting the compound aspartic polysaccharide and the indicators of 5-fold dose group were close to the normal level after14 days. 【Conclusion】The compound Asparagus cochinchinensis polysaccharide injection is an effective immune enhancer,which can promote the growth and development of chicken and is safe for actual production. The maximum tolerate dose in the target animal（chicken） is 10.0 mL/kg. |
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| Keywords: | compound Asparagus cochinchinensis polysaccharide injection target animals (chicken) weight feed conversion blood indicators blood biochemical parameters safety |
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