Tissue Distribution of Enrofloxacin in Fingerling Rainbow Trout Oncorhynchus mykiss Following Different Doses of Oral Administration |
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| Authors: | Hui-Min Hsu Gregory A Wooster Paul R Bowser |
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| Institution: | Department of Avian and Aquatic Animal Medicine. College of Veterinary Medicine. Cornell University, Irhaca. New York 14853 USA |
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| Abstract: | Rainbow trout Oncorhynchus mykiss were fed a ration medicated to provide enrofloxacin (Baytrilo®, Bayer) at 2.5, 5.0, or 10.0 mg drug per kg fish per d either 5 or 10 d. Tissue Concentrations of enrofloxacin were measured in liver, kidney, muscle, skin, and serum during the medication period, and thereafter for a total of 30 d. Highest tissue concentrations were observed in fish medicated with 5 mg enrofloxacin per kg fish per d for 10 d. Tissue concentrations of anitmicrobial activity were found to exceed minimum inhibitory concentrations of enrofloxacin for several isolates of Aeromonas salmonicida and Renibacterium salmoninarum . Lower than expected tissue concentrations were observed for the 10 mg per kg fish per d doses, perhaps due to a lack of acceptance of the medicated ration. The results support evaluation of a 5 mg per kg fish dose to treat bacterial infections of salmonids under field conditions. |
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