| 不同剂量替米考星对雏鸡心脏功能和呼吸的影响 |
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| 引用本文： | 利凯,张立永,马利芹,徐明举,杨永红,王杏.不同剂量替米考星对雏鸡心脏功能和呼吸的影响[J].中国畜牧兽医,2011,38(8):212-216. |
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| 作者姓名： | 利凯 张立永 马利芹 徐明举 杨永红 王杏 |
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| 作者单位： | 河北北方学院动物科技学院,河北张家口 075131 |
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| 摘 要： | 本试验将70只45日龄的罗曼鸡随机分成对照组和试验Ⅰ~Ⅵ组,旨在探讨不同剂量替米考星对雏鸡心功能和呼吸的影响。结果显示,随着替米考星剂量的加大和给药时间的延长,Ⅴ组死亡2只,Ⅵ组死亡4只;心率(HR)由增加到逐渐恢复,但5 h后,Ⅵ组HR极显著低于对照组(P＜0.01);左心室收缩压(LVSP)和左室内压最大变化速率(±dp/dtmax)呈逐渐下降趋势,左心室舒张末压(LVEDP)则逐渐升高,给药5 h后,Ⅳ、Ⅴ和Ⅵ组LVSP极显著低于对照组、Ⅰ、Ⅱ和Ⅲ组(P＜0.01),Ⅴ和Ⅵ组极显著低于Ⅳ组(P＜0.01)。Ⅱ组LVEDP显著高于对照组和Ⅰ组(P＜0.05),Ⅲ和Ⅳ组显著高于Ⅱ组(P＜0.05),极显著高于对照组和Ⅰ组(P＜0.01)。Ⅴ、Ⅵ组极显著高于其他各组(P＜0.01);Ⅰ~Ⅴ组呼吸逐渐加深加快。5 h后,Ⅲ、Ⅳ和Ⅴ组呼吸率显著高于对照组、Ⅰ和Ⅱ组(P＜0.05),但Ⅵ组呼吸率极显著低于Ⅲ、Ⅳ和Ⅴ组(P＜0.01)。提示替米考星在治疗雏鸡疾病时饮水安全使用剂量为400~600 mg/L,超过800 mg/L时会对心肺功能产生明显影响。
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| 关 键 词： | 替米考星 雏鸡 心功能 呼吸 |
Effect of Different Doses of Tilmicosin on Cardiac Function and Respiration of Chicken |
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| LI Kai,ZHANG Li-yong,MA Li-qin,XU Ming-ju,YANG Yong-hong,WANG Xing.Effect of Different Doses of Tilmicosin on Cardiac Function and Respiration of Chicken[J].China Animal Husbandry & Veterinary Medicine,2011,38(8):212-216. |
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| Authors: | LI Kai ZHANG Li-yong MA Li-qin XU Ming-ju YANG Yong-hong WANG Xing |
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| Institution: | College of Animal Science,Hebei North University,Zhangjiakou 075131,China |
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| Abstract: | 70 of the 45-day Roman chickens were randomly divided into control group and experimental Ⅰ-Ⅵ groups to explore the impact of different doses of Tilmicosin on cardiac function and respiratory. With increasing dose and administration time of Tilmicosin,the results showed that 2 died in Ⅴ group and 4 died in Ⅵ group; heart rate(HR) increased and then gradually restored. However,after 5 h,HR of Ⅵ group was significantly lower than the control group (P＜0.01); left ventricular systolic pressure (LVSP) and maximum rate of change of left ventricular pressure (±dp/dtmax) decreased gradually,the left ventricular end diastolic pressure (LVEDP) is increased gradually. 5 h after administration,LVSP of Ⅳ,Ⅴ and Ⅵ group was significantly lower than the control group,Ⅰ,Ⅱ and Ⅲ group (P＜0.01),Ⅴ and Ⅵ group was significantly lower than group Ⅳ (P＜0.01). LVEDP was significantly higher in group Ⅱ compared with the control group and Ⅰ group (P＜0.05),Ⅲ and Ⅳ were significantly higher than group Ⅱ (P＜0.05),and significantly higher than group Ⅰ (P＜0.01). Ⅴ and Ⅵ group was significantly higher than other groups (P＜0.01); Ⅰ-Ⅴ group breathing gradually deepened and accelerated. After 5 h,the respiration rate of Ⅲ,Ⅳ and Ⅴ were significantly higher than the control group,Ⅰ and Ⅱ group (P＜0.05),but the respiratory rate of Ⅵ group was significantly lower than Ⅲ,Ⅳ and Ⅴ groups (P＜0.01). In the treatment of diseases of chickens,the safe drinking water dose of Tilmicosin is 400-600 mg/L,more than 800 mg/L,has a significant impact on cardiopulmonary function. |
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| Keywords: | Tilmicosin chicken cardiac function respiratory |
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