| 氟苯尼考与盐酸土霉素体外联合抑菌效果研究 |
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| 引用本文： | 周文中,毕可东,邹本革,李红,邹明,张启迪.氟苯尼考与盐酸土霉素体外联合抑菌效果研究[J].中国畜牧兽医,2011,38(7):201-203. |
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| 作者姓名： | 周文中 毕可东 邹本革 李红 邹明 张启迪 |
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| 作者单位： | 1. 青岛农业大学动物科技学院,山东青岛 266109;2. 青岛农业大学海都学院,山东莱阳 265200;3. 山东栖霞市官道镇兽医站,山东栖霞 265316 |
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| 摘 要： | 为研究氟苯尼考和盐酸土霉素的临床配伍应用效果,本试验采用肉汤稀释棋盘法,对大肠杆菌、沙门氏菌等6株细菌进行了体外联合药敏试验。结果表明,单药对大肠杆菌和沙门氏菌标准株的MIC为1~8 μg/mL,对大肠杆菌和沙门氏菌临床株的MIC为64~128 μg/mL;联合用药的FIC指数分别为0.5、0.75、1.5、0.5、0.75、1.0,4株菌表现为相加作用,其余2株菌为协调作用和无关作用。
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| 关 键 词： | 氟苯尼考 盐酸土霉素 联合用药 |
| 收稿时间： | 2010-12-20 |
Studies on the Combined Antibacterial Activity of Florfenicol and Oxytetracycline Hydrochloride in vitro |
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| ZHOU Wen-zhong,BI Ke-dong,ZOU Ben-ge,LI Hong,ZOU Ming,ZHANG Qi-di.Studies on the Combined Antibacterial Activity of Florfenicol and Oxytetracycline Hydrochloride in vitro[J].China Animal Husbandry & Veterinary Medicine,2011,38(7):201-203. |
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| Authors: | ZHOU Wen-zhong BI Ke-dong ZOU Ben-ge LI Hong ZOU Ming ZHANG Qi-di |
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| Institution: | 1. College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China;2. College of Haidu,Qingdao Agricultural University, Laiyang 265200, China;3. Veterinary Station in Guandao Town, Qixia 265316, China |
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| Abstract: | The susceptibility test of Florfenicol and Oxytetracycline Hydrochloride on six strains of Escherichia coli and Salmonella was carried out by the broth dilution checkerboard method in order to study the combined antibacterial effect in clinical application in vitro. The results suggested that the MIC of single drug on the standard strains of Escherichia coli and Salmonella was 1 to 8 μg/mL, on the clinical strains was 64-128 μg/mL. The FIC of drug combination was 0.5, 0.75, 1.5, 0.5, 0.75, 1.0; there were four strains appeared additive effect while the other two strains appeared synergistic and irrelevant effect. |
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| Keywords: | Florfenicol Oxytetracycline Hydrochloride drug combination |
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