Fetal protection against bovine viral diarrhoea type 1 virus infection after one administration of a live-attenuated vaccine |
| |
| Authors: | Meyer Gilles Deplanche Martine Roux Dominique Moulignie Martine Picard-Hagen Nicole Lyazrhi Faouzi Raboisson Didier Mathevet Pierre Schelcher François |
| |
| Institution: | INRA, UMR1225, IHAP, F-31076 Toulouse, France. g.meyer@envt.fr |
| |
| Abstract: | A modified-live vaccine has been shown previously to prevent fetal infection with bovine viral diarrhoea virus (BVDV)-2 and, to some extent BVDV-1, when used in association with an inactivated vaccine in a two-step vaccination protocol. In this challenge study, the modified-live vaccine used alone was able to protect 13 heifers between 49 and 96 days of gestation at challenge from leucopenia and virus replication and, for a 4-month period, to prevent fetal infection. The efficacy of the BVDV-1f 22146/Han81 challenge was demonstrated by virus isolation from the fetuses of all nine non-vaccinated, control heifers. However, the small number of heifers tested meant that the vaccination failure rate could be as high as 10% in the field. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
