| 恩诺沙星在大口黑鲈(Micropterus salmoides)体内代谢动力学研究 |
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| 引用本文： | 何欣,王扬,贝亦江.恩诺沙星在大口黑鲈(Micropterus salmoides)体内代谢动力学研究[J].浙江农业学报,2018,30(9):1482. |
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| 作者姓名： | 何欣 王扬 贝亦江 |
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| 作者单位： | 1.杭州市农业科学研究院 实验中心,浙江 杭州 310024; 2.浙江省水产技术推广总站,浙江 杭州 310012 |
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| 摘 要： | 给大口黑鲈(Micropterus salmoides)连续5 d口服30 mg·kg-1剂量(以体质量计)的恩诺沙星,利用液相色谱技术测定不同时间点大口黑鲈各组织中恩诺沙星的含量,建立药时曲线,探讨恩诺沙星在大口黑鲈体内的代谢动力学。结果表明:在(25±2)℃水温下,大口黑鲈血液、肌肉、肝脏中恩诺沙星的达峰时间均为4 h,吸收半衰期分别为0.998、2.176、1.892 h,消除半衰期分别为8.494、23.84、37.53 h,血液中的药时曲线下总面积为132.23 μg·mL-1·h,肌肉和肝脏中的药时曲线下总面积分别为273.50、247.12 μg·g-1·h。25 ℃下,恩诺沙星在大口黑鲈体内的建议休药期为15 d。
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| 关 键 词： | 恩诺沙星 大口黑鲈 代谢动力学 |
| 收稿时间： | 2017-12-19 |
Pharmacokinetics of enrofloxacin in largemouth bass (Micropterus salmoides) |
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| HE Xin,WANG Yang,BEI Yijiang.Pharmacokinetics of enrofloxacin in largemouth bass (Micropterus salmoides)[J].Acta Agriculturae Zhejiangensis,2018,30(9):1482. |
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| Authors: | HE Xin WANG Yang BEI Yijiang |
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| Institution: | 1. Testing Center, Hangzhou Academy of Agricultural Sciences, Hangzhou 310024, China;
2. Zhejiang Fishery Technology Extension Center, Hangzhou 310012, China |
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| Abstract: | To investigate the metabolic rate of enrofloxacin in largemouth bass (Micropterus salmoides) and facilitate dosage decisions, the pharmacokinetics of enrofloxacin in largemouth bass were studied after 5 d fed with 30 mg·kg-1 (oral doses, based on body weight) enrofloxacin under (25±2) ℃. The concentrations of enrofloxacin in largemouth bass were determined by high performance liquid chromatography, and the drug-time curves were calculated. It was shown that the peak times of enrofloxacin in blood, muscle and liver were all 4 h under the experiment conditions. The absorption half lives of enrofloxacin in blood, muscle and liver were 0.998, 2.176, 1.892 h, respectively, and elimination half lives were 8.494, 23.84, 37.53 h, respectively. The area under drug concentration-time curves were 132.23 μg·mL-1·h in plasma and 273.50, 247.12 μg·g-1·h, respectively, in muscle and liver. Recommended withdrawal period of enrofloxacin in largemouth bass was 15 d under 25 ℃. |
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| Keywords: | enrofloxacin largemouth bass pharmacokinetics |
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