Serum cannabidiol,tetrahydrocannabinol (THC), and their native acid derivatives after transdermal application of a low-THC Cannabis sativa extract in beagles |
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| Authors: | Mary Beth Hannon Kelly A Deabold Bryce N Talsma Alex Lyubimov Asif Iqbal Alexander Zakharov Lauri Jo Gamble Joseph J Wakshlag |
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| Institution: | 1. Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA;2. University of Florida Comparative Diagnostic and Population Medicine, Gainesville, FL, USA;3. Toxicology Research Laboratory, Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA |
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| Abstract: | Cannabinoids hold promise for treating health problems related to inflammation and chronic pain in dogs, in particular cannabidiol (CBD), and its native acid derivative cannabidiolic acid (CBDA). Information regarding systemic delivery of cannabinoids through transdermal routes is sparse. The purpose of this study was to determine pharmacokinetics of transdermal administration of a low-THC Cannabis sativa extract in healthy dogs. Six purpose-bred research beagles were treated with a transdermal CBD-CBDA-rich extract, and serum concentrations of CBD, CBDA, tetrahydrocannabinol (THC), and its acid derivative tetrahydrocannabinolic acid (THCA) were examined prior to and at the end of weeks 1 and 2. A 4 mg/kg dose of total cannabinoids twice daily resulted in appx 10 ng/ml of CBD, 21–32 ng/ml of CBDA, trace amounts of THCA, and unquantifiable amounts of THC in serum at the end of weeks 1 and 2 of treatment. Results showed that CBDA and THCA were absorbed better systemically than CBD or THC. |
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| Keywords: | cannabidiol cannabidiolic acid dog hemp tetrahydrocannabinol transdermal |
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