Premature centromere division (PCD) identified in a hucul mare with reproductive difficulties |
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| Authors: | Wojciech Witarski Barbara Kij Agnieszka Nowak Monika Bugno-Poniewierska |
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| Institution: | 1. Department of Animal Genetics, National Institute of Animal Production, Balice, Poland;2. Department of Animal Reproduction, Anatomy and Genomics, University of Agriculture in Krakow, Krakow, Poland |
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| Abstract: | A hucul mare with reproductive abnormalities was examined during karyotype analysis. The karyotype was analysed based on evaluation of 860 metaphase plates in chromosome preparations. The use of fluorescence in situ hybridization (FISH) with an X chromosome painting probe showed premature X chromosome separation in 9.5% cases of examined chromosome spreads. In this report, we present the first identify premature centromere division (PCD) as a possible cause of abnormal X chromosome morphology in horses and as a probable cause of reproductive difficulties. |
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| Keywords: | FISH horses painting probe premature centromere division X chromosome |
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