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Pharmacokinetics and bioavailability of carbetocin after intravenous and intramuscular administration in cows and gilts |
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| Authors: | Pan Sun Hongzhi Xiao Jianzhong Wang Suxia Zhang Xingyuan Cao |
| Institution: | 1. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China;2. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, China Agricultural University, Beijing, China
Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China Key Laboratory of Detection for Veterinary Drug Residues and Illegal Additives, Ministry of Agriculture and Rural affairs of the People's Republic of China, Beijing, China |
| Abstract: | The pharmacokinetics of carbetocin, which is used to control postpartum hemorrhage after giving birth, was studied in cows and gilts after a single intravenous (IV) or intramuscular (IM) injection. Blood samples from animals were assessed by oxytocin radioimmunoassay, and then the pharmacokinetic parameters were calculated using a noncompartmental model. For gilts, there was no significant difference between half-life (T1/2λZ), mean residue time (MRT), and maximum concentration (Cmax) between IM and IV administration. Conversely, the time to reach the Cmax (Tmax) and MRT were higher following administration of 350 μg/animal in cows via the IM administration compared with IV. The longest T1/2λZ was 0.85 hr, indicating carbetocin was absorbed and eliminated rapidly in both animal species after administration. The Tmax was similar between cows and gilts following IM administration. Moreover, the Cmax after IM injection was about half that of IV administration in both animals. The bioavailability was more than 80% in cows, suggesting administration via the IM route is efficient. This is in agreement with the longer T1/2λZ in cows after IM administration. However, the IV route is recommended for gilts due to a lower bioavailability (35%) and shorter T1/2λZ after IM administration compared with IV. |
| Keywords: | bioavailability IM administration IV administration pharmacokinetics |