| 改性甘薯果胶对癌细胞增殖的影响 |
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| 引用本文： | 张燕燕,木泰华,张苗.改性甘薯果胶对癌细胞增殖的影响[J].中国农业科学,2012,45(9):1798-1806. |
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| 作者姓名： | 张燕燕 木泰华 张苗 |
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| 作者单位： | 1.中国农业科学院农产品加工研究所果蔬加工研究室，北京 100193 |
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| 基金项目： | 农业部现代农业产业技术体系建设专项(CARS-11-B-19);国际科技合作计划项目(2010DFA32690) |
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| 摘 要： | 【目的】探讨pH改性和热改性甘薯果胶对结肠癌细胞HT-29、乳腺癌细胞Bcap-37和肝癌细胞SMMC- 7721增殖的影响。【方法】分别对改性前后甘薯果胶的半乳糖醛酸含量、酯化度、分子量、微观结构及癌细胞增殖抑制活性进行测定。【结果】果胶改性后半乳糖醛酸含量显著提高（P＜0.05），而酯化度和分子量降低，微观结构发生明显变化。未改性、pH改性和热改性甘薯果胶对3种癌细胞均有抑制作用，并呈浓度和时间依赖性；改性后甘薯果胶对3种癌细胞增殖抑制效果均有显著提高（P＜0.05），且改性甘薯果胶对HT-29和Bcap-37的抑制效果更显著。【结论】改性甘薯果胶对HT-29和Bcap-37的增殖抑制效果较好，具有潜在的抗结肠癌和乳腺癌作用。
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| 关 键 词： | 甘薯果胶 改性 癌细胞 增殖 |
| 收稿时间： | 2012-01-06 |
Effects of Modified Sweet Potato Pectins on the Proliferation of Cancer Cells |
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| ZHANG Yan-yan
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MU Tai-hua
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ZHANG Miao.Effects of Modified Sweet Potato Pectins on the Proliferation of Cancer Cells[J].Scientia Agricultura Sinica,2012,45(9):1798-1806. |
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| Authors: | ZHANG Yan-yan MU Tai-hua ZHANG Miao |
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| Institution: | (Department of Fruit and Vegetable Processing,Institute of Agro-products Processing Science and Technology,Chinese Academy of Agricultural Sciences,Beijing 100193) |
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| Abstract: | 【Objective】Effects of pH-modified and heat-treated sweet potato pectins on proliferation of human colon cancer cell HT-29,human breast cancer cell Bcap-37 and human hepatoma cancer cell SMMC-7721 were investigated.【Method】The galacturonic acid content,degree of esterification(DE),molecular weight,microstructure and activity of cancer cell proliferation inhibition of pectins(natural,pH-modified and heat-treated pectins) were determined,respectively.【Result】Modification increased galacturonic acid content of sweet potato pectin,whereas decreased its DE and molecular weight significantly(P<0.05).The microstructures of modified pectins were obviously different from microstructure of natural pectin.Natural and modified sweet potato pectins could inhibit the proliferation of three types of cancer cells in time-and concentration-dependent manner.In addition,the inhibitory effect of modified sweet potato pectins on three types of cancer cells increased significantly compared to natural pectin(P<0.05).Furthermore,the proliferation-inhibitory effects of modified pectins on HT-29 and Bcap-37 were better than that of modified pectins on SMMC-7721.【Conclusion】Proliferation of HT-29 and Bcap-37 could be inhibited effectively by modified sweet potato pectins.It is,therefore,suggested that modified sweet potato pectins have potential applications in prevention of human colon cancer and breast cancer. |
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| Keywords: | sweet potato pectin modification cancer cells proliferation |
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